Next Article in Journal
Radical-Mediated Enzymatic Polymerizations
Previous Article in Journal
Transcriptome-Wide Identification and Expression Profiling Analysis of Chrysanthemum Trihelix Transcription Factors
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2016, 17(2), 194;

Methods to Design and Synthesize Antibody-Drug Conjugates (ADCs)

1,* and 1,*
Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China
Faculty of Materials Science and Chemical Engineering, the State Key Laboratory Base of Novel Functional Materials and Preparation Science, Ningbo University, Ningbo 315211, Zhejiang, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editor: Már Másson
Received: 11 January 2016 / Revised: 28 January 2016 / Accepted: 28 January 2016 / Published: 2 February 2016
(This article belongs to the Section Biochemistry)
Full-Text   |   PDF [4709 KB, uploaded 2 February 2016]   |  


Antibody-drug conjugates (ADCs) have become a promising targeted therapy strategy that combines the specificity, favorable pharmacokinetics and biodistributions of antibodies with the destructive potential of highly potent drugs. One of the biggest challenges in the development of ADCs is the application of suitable linkers for conjugating drugs to antibodies. Recently, the design and synthesis of linkers are making great progress. In this review, we present the methods that are currently used to synthesize antibody-drug conjugates by using thiols, amines, alcohols, aldehydes and azides. View Full-Text
Keywords: antibody-drug conjugates (ADCs); targeted therapy; monoclonal antibodies (mAbs); drugs; linkers antibody-drug conjugates (ADCs); targeted therapy; monoclonal antibodies (mAbs); drugs; linkers

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Yao, H.; Jiang, F.; Lu, A.; Zhang, G. Methods to Design and Synthesize Antibody-Drug Conjugates (ADCs). Int. J. Mol. Sci. 2016, 17, 194.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top