Next Article in Journal
Down-Regulation of Ca2+-Activated K+ Channel KCa1.1 in Human Breast Cancer MDA-MB-453 Cells Treated with Vitamin D Receptor Agonists
Next Article in Special Issue
NAFLD: Is There Anything New under the Sun?
Previous Article in Journal
Antithymocyte Globulin Induces a Tolerogenic Phenotype in Human Dendritic Cells
Previous Article in Special Issue
Molecular Pathogenesis of NASH
Review

Pathophysiology of Non Alcoholic Fatty Liver Disease

1
Gastroenterology, Di.Bi.M.I.S Policlinic Paolo Giaccone Hospital, University of Palermo, PC 90127, Palermo, Italy
2
Cardiometabolic Risk Unit—Institute of Clinical Physiology, CNR, PC 56124, Pisa, Italy
3
Department of Clinical and Experimental Medicine, University of Pisa, PC 56122, Pisa, Italy
4
Gastroenterology and Hepatology, Department of Medical Sciences, Città della, Salute e della Scienza di Torino Hospital, University of Turin, PC 10122, Turin, Italy
5
Department of Nephrology, Urology and Renal Transplant—Fondazione IRCCS Ca’, Granda, PC 20122 Milano, Italy
6
Institute of Internal Medicine, Gastroenterology and Liver Diseases Unit, Fondazione Policlinico Gemelli, Catholic University of Rome, PC 00168, Rome, Italy
7
Department of Gastroenterology 1 and Obesity 2, Polytechnic University of Marche, PC 60121, Ancona, Italy
8
Metabolic Liver Diseases—Università degli Studi Milano-Fondazione IRCCS Ca’, Granda via F Sforza 35, PC 20122 Milano, Italy
9
Institute for Health, PC 53042, Chianciano Terme, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Amedeo Lonardo and Giovanni Targher
Int. J. Mol. Sci. 2016, 17(12), 2082; https://doi.org/10.3390/ijms17122082
Received: 22 September 2016 / Revised: 30 November 2016 / Accepted: 1 December 2016 / Published: 11 December 2016
(This article belongs to the Special Issue Non-Alcoholic Fatty Liver Disease Research 2016)
The physiopathology of fatty liver and metabolic syndrome are influenced by diet, life style and inflammation, which have a major impact on the severity of the clinicopathologic outcome of non-alcoholic fatty liver disease. A short comprehensive review is provided on current knowledge of the pathophysiological interplay among major circulating effectors/mediators of fatty liver, such as circulating lipids, mediators released by adipose, muscle and liver tissues and pancreatic and gut hormones in relation to diet, exercise and inflammation. View Full-Text
Keywords: fatty liver; insulin resistance; free fatty acids; cholesterol; adiponectin; leptin; insulin; glucagon; glucagon-like peptide 1; ghrelin; irisin; selenoprotein P fatty liver; insulin resistance; free fatty acids; cholesterol; adiponectin; leptin; insulin; glucagon; glucagon-like peptide 1; ghrelin; irisin; selenoprotein P
Show Figures

Figure 1

MDPI and ACS Style

Petta, S.; Gastaldelli, A.; Rebelos, E.; Bugianesi, E.; Messa, P.; Miele, L.; Svegliati-Baroni, G.; Valenti, L.; Bonino, F. Pathophysiology of Non Alcoholic Fatty Liver Disease. Int. J. Mol. Sci. 2016, 17, 2082. https://doi.org/10.3390/ijms17122082

AMA Style

Petta S, Gastaldelli A, Rebelos E, Bugianesi E, Messa P, Miele L, Svegliati-Baroni G, Valenti L, Bonino F. Pathophysiology of Non Alcoholic Fatty Liver Disease. International Journal of Molecular Sciences. 2016; 17(12):2082. https://doi.org/10.3390/ijms17122082

Chicago/Turabian Style

Petta, Salvatore, Amalia Gastaldelli, Eleni Rebelos, Elisabetta Bugianesi, Piergiorgio Messa, Luca Miele, Gianluca Svegliati-Baroni, Luca Valenti, and Ferruccio Bonino. 2016. "Pathophysiology of Non Alcoholic Fatty Liver Disease" International Journal of Molecular Sciences 17, no. 12: 2082. https://doi.org/10.3390/ijms17122082

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop