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Int. J. Mol. Sci. 2016, 17(12), 2082;

Pathophysiology of Non Alcoholic Fatty Liver Disease

Gastroenterology, Di.Bi.M.I.S Policlinic Paolo Giaccone Hospital, University of Palermo, PC 90127, Palermo, Italy
Cardiometabolic Risk Unit—Institute of Clinical Physiology, CNR, PC 56124, Pisa, Italy
Department of Clinical and Experimental Medicine, University of Pisa, PC 56122, Pisa, Italy
Gastroenterology and Hepatology, Department of Medical Sciences, Città della, Salute e della Scienza di Torino Hospital, University of Turin, PC 10122, Turin, Italy
Department of Nephrology, Urology and Renal Transplant—Fondazione IRCCS Ca’, Granda, PC 20122 Milano, Italy
Institute of Internal Medicine, Gastroenterology and Liver Diseases Unit, Fondazione Policlinico Gemelli, Catholic University of Rome, PC 00168, Rome, Italy
Department of Gastroenterology 1 and Obesity 2, Polytechnic University of Marche, PC 60121, Ancona, Italy
Metabolic Liver Diseases—Università degli Studi Milano-Fondazione IRCCS Ca’, Granda via F Sforza 35, PC 20122 Milano, Italy
Institute for Health, PC 53042, Chianciano Terme, Italy
Author to whom correspondence should be addressed.
Academic Editors: Amedeo Lonardo and Giovanni Targher
Received: 22 September 2016 / Revised: 30 November 2016 / Accepted: 1 December 2016 / Published: 11 December 2016
(This article belongs to the Special Issue Non-Alcoholic Fatty Liver Disease Research 2016)
Full-Text   |   PDF [516 KB, uploaded 13 December 2016]   |  


The physiopathology of fatty liver and metabolic syndrome are influenced by diet, life style and inflammation, which have a major impact on the severity of the clinicopathologic outcome of non-alcoholic fatty liver disease. A short comprehensive review is provided on current knowledge of the pathophysiological interplay among major circulating effectors/mediators of fatty liver, such as circulating lipids, mediators released by adipose, muscle and liver tissues and pancreatic and gut hormones in relation to diet, exercise and inflammation. View Full-Text
Keywords: fatty liver; insulin resistance; free fatty acids; cholesterol; adiponectin; leptin; insulin; glucagon; glucagon-like peptide 1; ghrelin; irisin; selenoprotein P fatty liver; insulin resistance; free fatty acids; cholesterol; adiponectin; leptin; insulin; glucagon; glucagon-like peptide 1; ghrelin; irisin; selenoprotein P

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Petta, S.; Gastaldelli, A.; Rebelos, E.; Bugianesi, E.; Messa, P.; Miele, L.; Svegliati-Baroni, G.; Valenti, L.; Bonino, F. Pathophysiology of Non Alcoholic Fatty Liver Disease. Int. J. Mol. Sci. 2016, 17, 2082.

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