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Int. J. Mol. Sci. 2016, 17(12), 1990;

Immune-Related Gene Expression Patterns in GPV- or H9N2-Infected Goose Spleens

1,2,3,†,* , 1,†
Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu 611130, China
Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editor: Johannes Haybaeck
Received: 20 September 2016 / Revised: 19 November 2016 / Accepted: 22 November 2016 / Published: 1 December 2016
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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Goose parvovirus (GPV) and avian influenza virus subtype H9N2 are single-stranded DNA (ssDNA) and single-stranded RNA (ssRNA) viruses, respectively, both of which can spread in goslings and cause a significant economic loss. To explore the comprehensive transcriptome of GPV- or H9N2-infected goose spleens and to understand the immune responses induced by a DNA virus (GPV) or a RNA virus (H9N2), RNA-seq was performed on the spleens of goslings at the fifth day post infection. In the present study, 2604 and 2409 differentially expressed unigenes were identified in the GPV- and H9N2-infected groups, respectively. Through KEGG pathway enrichment analyses, the up-regulated transcripts in the two virus-infected groups were mainly involved in immune-related pathways. In addition, the two virus-infected groups displayed similar expression patterns in the immune response pathways, including pattern-recognition receptor signaling pathways, the antigen processing and presentation pathway, the NF-κB signaling pathway and the JAK-STAT signaling pathway, as well as cytokines. Furthermore, most of the immune-related genes, particularly TLR7, TRAF3, Mx, TRIM25, CD4, and CD8α, increased in response to GPV and H9N2 infection. However, the depression of NF-κB signaling may be a mechanism by which the viruses evade the host immune system or a strategy to achieve immune homeostasis. View Full-Text
Keywords: identical expression profile; systemic transcriptome; GPV; H9N2 identical expression profile; systemic transcriptome; GPV; H9N2

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Chen, S.; Wang, A.; Sun, L.; Liu, F.; Wang, M.; Jia, R.; Zhu, D.; Liu, M.; Yang, Q.; Wu, Y.; Sun, K.; Chen, X.; Cheng, A. Immune-Related Gene Expression Patterns in GPV- or H9N2-Infected Goose Spleens. Int. J. Mol. Sci. 2016, 17, 1990.

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