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Open AccessArticle

Characterizing Non-Tuberculous Mycobacteria Infection in Bronchiectasis

1
Dipartimento Cardio-Toraco-Vascolare, University of Milan Bicocca, Respiratory Unit, San Gerardo Hospital, ASST di Monza, Via Pergolesi 33, 20900 Monza, Italy
2
Department of Internal Medicine, Division of Infectious Diseases, San Gerardo Hospital, ASST di Monza, Via Pergolesi 33, 20900 Monza, Italy
3
Department of Pathophysiology and Transplantation, University of Milan, Cardio-Thoracic Unit and Cystic Fibrosis Adult Center, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy
4
Villa Marelli Institute, Niguarda Ca’ Granda Hospital, 20122 Milan, Italy
5
Scottish Centre for Respiratory Research, University of Dundee, Dundee DD1 9SY, UK
6
Host Defence Unit, Royal Brompton and Harefield NHS Foundation Trust, London, UK Imperial College London, London SW3 6NP, UK
*
Author to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Int. J. Mol. Sci. 2016, 17(11), 1913; https://doi.org/10.3390/ijms17111913
Received: 16 September 2016 / Revised: 3 November 2016 / Accepted: 7 November 2016 / Published: 16 November 2016
(This article belongs to the Special Issue Lung Diseases: Chronic Respiratory Infections)
Chronic airway infection is a key aspect of the pathogenesis of bronchiectasis. A growing interest has been raised on non-tuberculous mycobacteria (NTM) infection. We aimed at describing the clinical characteristics, diagnostic process, therapeutic options and outcomes of bronchiectasis patients with pulmonary NTM (pNTM) disease. This was a prospective, observational study enrolling 261 adult bronchiectasis patients during the stable state at the San Gerardo Hospital, Monza, Italy, from 2012 to 2015. Three groups were identified: pNTM disease; chronic P. aeruginosa infection; chronic infection due to bacteria other than P. aeruginosa. NTM were isolated in 32 (12%) patients, and among them, a diagnosis of pNTM disease was reached in 23 cases. When compared to chronic P. aeruginosa infection, patients with pNTM were more likely to have cylindrical bronchiectasis and a “tree-in-bud” pattern, a history of weight loss, a lower disease severity and a lower number of pulmonary exacerbations. Among pNTM patients who started treatment, 68% showed a radiological improvement, and 37% achieved culture conversion without recurrence, while 21% showed NTM isolation recurrence. NTM isolation seems to be a frequent event in bronchiectasis patients, and few parameters might help to suspect NTM infection. Treatment indications and monitoring still remain an important area for future research. View Full-Text
Keywords: non-cystic fibrosis bronchiectasis; non-tuberculous mycobacteria; pulmonary infection non-cystic fibrosis bronchiectasis; non-tuberculous mycobacteria; pulmonary infection
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MDPI and ACS Style

Faverio, P.; Stainer, A.; Bonaiti, G.; Zucchetti, S.C.; Simonetta, E.; Lapadula, G.; Marruchella, A.; Gori, A.; Blasi, F.; Codecasa, L.; Pesci, A.; Chalmers, J.D.; Loebinger, M.R.; Aliberti, S. Characterizing Non-Tuberculous Mycobacteria Infection in Bronchiectasis. Int. J. Mol. Sci. 2016, 17, 1913. https://doi.org/10.3390/ijms17111913

AMA Style

Faverio P, Stainer A, Bonaiti G, Zucchetti SC, Simonetta E, Lapadula G, Marruchella A, Gori A, Blasi F, Codecasa L, Pesci A, Chalmers JD, Loebinger MR, Aliberti S. Characterizing Non-Tuberculous Mycobacteria Infection in Bronchiectasis. International Journal of Molecular Sciences. 2016; 17(11):1913. https://doi.org/10.3390/ijms17111913

Chicago/Turabian Style

Faverio, Paola; Stainer, Anna; Bonaiti, Giulia; Zucchetti, Stefano C.; Simonetta, Edoardo; Lapadula, Giuseppe; Marruchella, Almerico; Gori, Andrea; Blasi, Francesco; Codecasa, Luigi; Pesci, Alberto; Chalmers, James D.; Loebinger, Michael R.; Aliberti, Stefano. 2016. "Characterizing Non-Tuberculous Mycobacteria Infection in Bronchiectasis" Int. J. Mol. Sci. 17, no. 11: 1913. https://doi.org/10.3390/ijms17111913

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