Next Article in Journal
Why Are Omics Technologies Important to Understanding the Role of Nutrition in Inflammatory Bowel Diseases?
Next Article in Special Issue
Programmed Effects in Neurobehavior and Antioxidative Physiology in Zebrafish Embryonically Exposed to Cadmium: Observations and Hypothesized Adverse Outcome Pathway Framework
Previous Article in Journal
Towards Stratified Medicine in Plasma Cell Myeloma
Previous Article in Special Issue
Exposure to Zinc Sulfate Results in Differential Effects on Olfactory Sensory Neuron Subtypes in Adult Zebrafish
Open AccessArticle

Screening the Toxicity of Selected Personal Care Products Using Embryo Bioassays: 4-MBC, Propylparaben and Triclocarban

1
CIMAR/CIIMAR, Laboratório Associado—Centro Interdisciplinar de Investigação Marinha e Ambiental, Universidade do Porto, Av. General Norton de Matos s/n, 4450-208 Porto, Portugal
2
Escola Superior de Tecnologia de Saúde do Porto, Instituto Politécnico do Porto, 4200-072 Porto, Portugal
3
FCUP-Departamento de Biologia, Faculdade de Ciências da Universidade do Porto, Rua do Campo Alegre, 4169-007 Porto, Portugal
*
Author to whom correspondence should be addressed.
Academic Editor: Juliette Legler
Int. J. Mol. Sci. 2016, 17(10), 1762; https://doi.org/10.3390/ijms17101762
Received: 9 August 2016 / Revised: 17 September 2016 / Accepted: 10 October 2016 / Published: 21 October 2016
(This article belongs to the Special Issue Zebrafish: A Model for Toxicological Research)
Recently, several emerging pollutants, including Personal Care Products (PCPs), have been detected in aquatic ecosystems, in the ng/L or µg/L range. Available toxicological data is limited, and, for certain PCPs, evidence indicates a potential risk for the environment. Hence, there is an urgent need to gather ecotoxicological data on PCPs as a proxy to improve risk assessment. Here, the toxicity of three different PCPs (4-Methylbenzylidene Camphor (4-MBC), propylparaben and triclocarban) was tested using embryo bioassays with Danio rerio (zebrafish) and Paracentrotus lividus (sea urchin). The No Observed Effect Concentration (NOEC) for triclocarban was 0.256 µg/L for sea urchin and 100 µg/L for zebrafish, whereas NOEC for 4-MBC was 0.32 µg/L for sea urchin and 50 µg/L for zebrafish. Both PCPs impacted embryo development at environmentally relevant concentrations. In comparison with triclocarban and 4-MBC, propylparaben was less toxic for both sea urchin (NOEC = 160 µg/L) and zebrafish (NOEC = 1000 µg/L). Overall, this study further demonstrates the sensitivity of embryo bioassays as a high-throughput approach for testing the toxicity of emerging pollutants. View Full-Text
Keywords: personal care products; sea urchin; zebrafish; embryo bioassays; risk assessment; 4-Methylbenzylidene Camphor; propylparaben; triclocarban; Registration; Evaluation; Authorization; and Restriction of Chemicals (REACH) personal care products; sea urchin; zebrafish; embryo bioassays; risk assessment; 4-Methylbenzylidene Camphor; propylparaben; triclocarban; Registration; Evaluation; Authorization; and Restriction of Chemicals (REACH)
Show Figures

Figure 1

MDPI and ACS Style

Torres, T.; Cunha, I.; Martins, R.; Santos, M.M. Screening the Toxicity of Selected Personal Care Products Using Embryo Bioassays: 4-MBC, Propylparaben and Triclocarban. Int. J. Mol. Sci. 2016, 17, 1762.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop