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Int. J. Mol. Sci. 2016, 17(1), 33;

Targeted Radionuclide Therapy of Human Tumors

Laboratory of Optical Theranostics, Lobachevsky Nizhny Novgorod State University, Gagarin Ave. 23, Nizhny Novgorod 603950, Russia
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya St, 3, Pushchino, Moscow 142290, Russia
Prokhorov Institute of General Physics, Russian Academy of Sciences, Vavilova St, 38, Moscow 119991, Russia
ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP), Macquarie University, Sydney 2109, Australia
Author to whom correspondence should be addressed.
Academic Editors: William Chi-shing Cho and Anthony Lemarié
Received: 26 September 2015 / Revised: 7 December 2015 / Accepted: 22 December 2015 / Published: 28 December 2015
(This article belongs to the Special Issue Molecular Classification of Human Cancer: Diagnosis and Treatment)
Full-Text   |   PDF [1378 KB, uploaded 28 December 2015]   |  


Targeted radionuclide therapy is one of the most intensively developing directions of nuclear medicine. Unlike conventional external beam therapy, the targeted radionuclide therapy causes less collateral damage to normal tissues and allows targeted drug delivery to a clinically diagnosed neoplastic malformations, as well as metastasized cells and cellular clusters, thus providing systemic therapy of cancer. The methods of targeted radionuclide therapy are based on the use of molecular carriers of radionuclides with high affinity to antigens on the surface of tumor cells. The potential of targeted radionuclide therapy has markedly grown nowadays due to the expanded knowledge base in cancer biology, bioengineering, and radiochemistry. In this review, progress in the radionuclide therapy of hematological malignancies and approaches for treatment of solid tumors is addressed. View Full-Text
Keywords: radio-immunotherapy; radionuclide; targeted therapy; α-emitter; β-emitter; Auger electron; antibody; peptide radio-immunotherapy; radionuclide; targeted therapy; α-emitter; β-emitter; Auger electron; antibody; peptide

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Gudkov, S.V.; Shilyagina, N.Y.; Vodeneev, V.A.; Zvyagin, A.V. Targeted Radionuclide Therapy of Human Tumors. Int. J. Mol. Sci. 2016, 17, 33.

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