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Int. J. Mol. Sci. 2016, 17(1), 10;

Research Advances on Pathways of Nickel-Induced Apoptosis

1,2,* , 1,2
Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agricultural University, Ya’an 625014, China
College of Veterinary Medicine, Sichuan Agricultural University Ya’an, Ya’an 625014, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Anthony Lemarié
Received: 22 September 2015 / Revised: 15 December 2015 / Accepted: 16 December 2015 / Published: 23 December 2015
(This article belongs to the Collection Programmed Cell Death and Apoptosis)
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High concentrations of nickel (Ni) are harmful to humans and animals. Ni targets a number of organs and produces multiple toxic effects. Apoptosis is important in Ni-induced toxicity of the kidneys, liver, nerves, and immune system. Apoptotic pathways mediated by reactive oxygen species (ROS), mitochondria, endoplasmic reticulum (ER), Fas, and c-Myc participate in Ni-induced cell apoptosis. However, the exact mechanism of apoptosis caused by Ni is still unclear. Understanding the mechanism of Ni-induced apoptosis may help in designing measures to prevent Ni toxicity. View Full-Text
Keywords: Ni; apoptosis; molecular mechanism; mitochondria; endoplasmic reticulum Ni; apoptosis; molecular mechanism; mitochondria; endoplasmic reticulum

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Guo, H.; Chen, L.; Cui, H.; Peng, X.; Fang, J.; Zuo, Z.; Deng, J.; Wang, X.; Wu, B. Research Advances on Pathways of Nickel-Induced Apoptosis. Int. J. Mol. Sci. 2016, 17, 10.

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