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Int. J. Mol. Sci. 2015, 16(9), 23012-23034;

Quo Vadis Clozapine? A Bibliometric Study of 45 Years of Research in International Context

Faculty of Health Sciences and Chair of Genomic Medicine, Camilo José Cela University, C/Castillo de Alarcón, 49, Urb. Villafranca del Castillo, 28692 Villanueva de la Cañada, Madrid, Spain
Department of Biomedical Sciences (Pharmacology Area), Faculty of Medicine and Health Sciences, University of Alcalá, Campus Universitario-C/19, Ctra. Madrid-Barcelona, Km. 33,600, 28871 Alcalá de Henares, Madrid, Spain
Neuropsychopharmacology Unit, “Hospital 12 de Octubre” Research Institute, Avda. Córdoba, s/n, Madrid 28041, Spain
Department of Psychiatry, 12 de Octubre University Hospital, Avda. Córdoba, s/n, Madrid 28041, Spain
Biomedical Research Center Network for Mental Health (CIBERSAM), Madrid 28029, Spain
Department of Psychiatry, Complutense University, Plaza de Ramón y Cajal, s/n, Ciudad Universitaria, Madrid 28040, Spain
Networks for Cooperative Research in Health (RETICS-Addictive Disorder Network), Institute of Health Carlos III (ISCIII), MICINN and FEDER, Madrid 28029, Spain
Author to whom correspondence should be addressed.
Academic Editor: Domenico De Berardis
Received: 30 July 2015 / Revised: 4 September 2015 / Accepted: 13 September 2015 / Published: 23 September 2015
(This article belongs to the Special Issue Antipsychotics)
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We have carried out a bibliometric study about the international scientific publications on clozapine. We have used the EMBASE and MEDLINE databases, and we applied bibliometric indicators of production, as Price’s Law on the increase of scientific literature. We also calculated the participation index (PI) of the different countries. The bibliometric data have also been correlated with some social and health data from the 12 most productive countries in biomedicine and health sciences. In addition, 5607 original documents dealing with clozapine, published between 1970 and 2013, were downloaded. Our results state non-fulfilment of Price’s Law, with scientific production on clozapine showing linear growth (r = 0.8691, vs. r = 0.8478 after exponential adjustment). Seven of the 12 journals with the highest numbers of publications on clozapine have an Impact Factor > 2. Among the countries generating clozapine research, the most prominent is the USA (PI = 24.32), followed by the UK (PI = 6.27) and Germany (PI = 5.40). The differences among countries on clozapine research are significantly related to economic variables linked to research. The scientific interest in clozapine remains remarkable, although after the application of bibliometric indicators of production, a saturation point is evident in the growth of scientific literature on this topic. View Full-Text
Keywords: clozapine; atypical antipsychotics; second-generation antipsychotics; bibliometry; schizophrenia clozapine; atypical antipsychotics; second-generation antipsychotics; bibliometry; schizophrenia

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López-Muñoz, F.; Sanz-Fuentenebro, J.; Rubio, G.; García-García, P.; Álamo, C. Quo Vadis Clozapine? A Bibliometric Study of 45 Years of Research in International Context. Int. J. Mol. Sci. 2015, 16, 23012-23034.

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