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Brain-Specific Cytoskeletal Damage Markers in Cerebrospinal Fluid: Is There a Common Pattern between Amyotrophic Lateral Sclerosis and Primary Progressive Multiple Sclerosis?

1
Department of Neurology, Ulm University, Oberer Eselsberg 45, 89081 Ulm, Germany
2
Institute of Neuropathology, University Hospital Göttingen, Robert-Koch-Str 40, 37075 Göttingen, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Christoph Kleinschnitz
Int. J. Mol. Sci. 2015, 16(8), 17565-17588; https://doi.org/10.3390/ijms160817565
Received: 16 June 2015 / Revised: 20 July 2015 / Accepted: 23 July 2015 / Published: 31 July 2015
(This article belongs to the Special Issue Advances in Multiple Sclerosis)
Many neurodegenerative disorders share a common pathophysiological pathway involving axonal degeneration despite different etiological triggers. Analysis of cytoskeletal markers such as neurofilaments, protein tau and tubulin in cerebrospinal fluid (CSF) may be a useful approach to detect the process of axonal damage and its severity during disease course. In this article, we review the published literature regarding brain-specific CSF markers for cytoskeletal damage in primary progressive multiple sclerosis and amyotrophic lateral sclerosis in order to evaluate their utility as a biomarker for disease progression in conjunction with imaging and histological markers which might also be useful in other neurodegenerative diseases associated with affection of the upper motor neurons. A long-term benefit of such an approach could be facilitating early diagnostic and prognostic tools and assessment of treatment efficacy of disease modifying drugs. View Full-Text
Keywords: primary progressive multiple sclerosis (PPMS); amyotrophic lateral sclerosis (ALS); neurofilaments; biomarker; tau; tubulin primary progressive multiple sclerosis (PPMS); amyotrophic lateral sclerosis (ALS); neurofilaments; biomarker; tau; tubulin
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Abdelhak, A.; Junker, A.; Brettschneider, J.; Kassubek, J.; Ludolph, A.C.; Otto, M.; Tumani, H. Brain-Specific Cytoskeletal Damage Markers in Cerebrospinal Fluid: Is There a Common Pattern between Amyotrophic Lateral Sclerosis and Primary Progressive Multiple Sclerosis? Int. J. Mol. Sci. 2015, 16, 17565-17588.

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