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Association between the NF-E2 Related Factor 2 Gene Polymorphism and Oxidative Stress, Anti-Oxidative Status, and Newly-Diagnosed Type 2 Diabetes Mellitus in a Chinese Population

Department of Maternal and Child Health Care, School of Public Health, Shandong University, Jinan 250012, China
Department of Nutrition and Food Hygiene and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Institute of Biomedicine, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China
Authors to whom correspondence should be addressed.
Academic Editor: Emil Alexov
Int. J. Mol. Sci. 2015, 16(7), 16483-16496;
Received: 21 March 2015 / Revised: 14 June 2015 / Accepted: 30 June 2015 / Published: 20 July 2015
(This article belongs to the Collection Human Single Nucleotide Polymorphisms and Disease Diagnostics)
PDF [698 KB, uploaded 20 July 2015]


Oxidative stress is a major risk factor in the onset and progression of type 2 diabetes mellitus (T2DM). NF-E2 related factor 2 (NRF2) is a pivotal transcription factor in oxidative stress related illnesses. This study included 2174 subjects with 879 cases of newly-diagnosed T2DM and 1295 healthy controls. Compared to individuals with the CC genotype, those with the AA genotype had lower total anti-oxidative capacity, superoxide dismutase, catalase, glutathione, glutathione peroxidase activity; and lower homeostasis model assessment of β-cell function index. Those with the AA genotype also had a higher malondialdehyde concentration and homeostasis model assessment of insulin resistance index values. The frequency of allele A was significantly higher in T2DM subjects (29.4%), compared to control subjects (26.1%; p = 0.019). Individuals with the AA genotype had a significantly higher risk of developing T2DM (OR 1.56; 95% CI 1.11, 2.20; p = 0.011), relative to those with the CC genotype, even after adjusting for known T2DM risk factors. Our results suggest that the NRF2 rs6721961 polymorphism was significantly associated with oxidative stress, anti-oxidative status, and risk of newly-diagnosed T2DM. This polymorphism may also contribute to impaired insulin secretory capacity and increased insulin resistance in a Chinese population. View Full-Text
Keywords: NRF2; oxidative stress; polymorphism; type 2 diabetes NRF2; oxidative stress; polymorphism; type 2 diabetes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Wang, X.; Chen, H.; Liu, J.; Ouyang, Y.; Wang, D.; Bao, W.; Liu, L. Association between the NF-E2 Related Factor 2 Gene Polymorphism and Oxidative Stress, Anti-Oxidative Status, and Newly-Diagnosed Type 2 Diabetes Mellitus in a Chinese Population. Int. J. Mol. Sci. 2015, 16, 16483-16496.

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