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Int. J. Mol. Sci. 2015, 16(7), 14961-14978;

Therapeutic Potential of Differentiated Mesenchymal Stem Cells for Treatment of Osteoarthritis

Catholic Kwandong University International St. Mary's Hospital, Incheon 404-834, Korea
Department of Integrated Omics for Biomedical Sciences, Yonsei University, 50 Yonsei-ro, Seodamun-gu, Seoul 120-759, Korea
Department of Biology Education, College of Education, Pusan National University, Busan 609-735, Korea
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
Department of Molecular Physiology, College of Pharmacy, Kyungpook National University, Daegu 702-701, Korea
Department of Life Systems, Sookmyung Women's University, Seoul 140-742, Korea
Institute of Catholic Integrative Medicine, Incheon St. Mary's Hospital, the Catholic University of Korea, College of Medicine, Incheon 403-720, Korea
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editor: Wilhelm Bloch
Received: 22 April 2015 / Revised: 24 June 2015 / Accepted: 26 June 2015 / Published: 2 July 2015
(This article belongs to the Special Issue Stem Cell Activation in Adult Organism)
Full-Text   |   PDF [708 KB, uploaded 2 July 2015]


Osteoarthritis (OA) is a chronic, progressive, and irreversible degenerative joint disease. Conventional OA treatments often result in complications such as pain and limited activity. However, transplantation of mesenchymal stem cells (MSCs) has several beneficial effects such as paracrine effects, anti-inflammatory activity, and immunomodulatory capacity. In addition, MSCs can be differentiated into several cell types, including chondrocytes, osteocytes, endothelia, and adipocytes. Thus, transplantation of MSCs is a suggested therapeutic tool for treatment of OA. However, transplanted naïve MSCs can cause problems such as heterogeneous populations including differentiated MSCs and undifferentiated cells. To overcome this problem, new strategies for inducing differentiation of MSCs are needed. One possibility is the application of microRNA (miRNA) and small molecules, which regulate multiple molecular pathways and cellular processes such as differentiation. Here, we provide insight into possible strategies for cartilage regeneration by transplantation of differentiated MSCs to treat OA patients. View Full-Text
Keywords: osteoarthritis; mesenchymal stem cells; microRNA; small molecule; differentiation osteoarthritis; mesenchymal stem cells; microRNA; small molecule; differentiation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Ham, O.; Lee, C.Y.; Kim, R.; Lee, J.; Oh, S.; Lee, M.Y.; Kim, J.; Hwang, K.-C.; Maeng, L.-S.; Chang, W. Therapeutic Potential of Differentiated Mesenchymal Stem Cells for Treatment of Osteoarthritis. Int. J. Mol. Sci. 2015, 16, 14961-14978.

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