Next Article in Journal
Detection of Serum Protein Biomarkers for the Diagnosis and Staging of Hepatoblastoma
Next Article in Special Issue
Structural Diversity of Copper(II) Complexes with 9-Deazahypoxanthine and Their in Vitro SOD-Like Activity
Previous Article in Journal
Efficient Synthesis of Peptide and Protein Functionalized Pyrrole-Imidazole Polyamides Using Native Chemical Ligation
Open AccessReview

Vanadium Compounds as Pro-Inflammatory Agents: Effects on Cyclooxygenases

Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstańców Wlkp. 72 Av., 70-111 Szczecin, Poland
Department of Biochemistry and Human Nutrition, Pomeranian Medical University, Broniewskiego 24 Str., 71-460 Szczecin, Poland
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Kaixun Huang
Int. J. Mol. Sci. 2015, 16(6), 12648-12668;
Received: 14 April 2015 / Revised: 12 May 2015 / Accepted: 19 May 2015 / Published: 4 June 2015
(This article belongs to the Special Issue Applied Bioinorganic Chemistry and Selected Papers from 13th ISABC)
This paper discusses how the activity and expression of cyclooxygenases are influenced by vanadium compounds at anticancer concentrations and recorded in inorganic vanadium poisonings. We refer mainly to the effects of vanadate (orthovanadate), vanadyl and pervanadate ions; the main focus is placed on their impact on intracellular signaling. We describe the exact mechanism of the effect of vanadium compounds on protein tyrosine phosphatases (PTP), epidermal growth factor receptor (EGFR), PLCγ, Src, mitogen-activated protein kinase (MAPK) cascades, transcription factor NF-κB, the effect on the proteolysis of COX-2 and the activity of cPLA2. For a better understanding of these processes, a lot of space is devoted to the transformation of vanadium compounds within the cell and the molecular influence on the direct targets of the discussed vanadium compounds. View Full-Text
Keywords: vanadium; tyrosine phosphatase; cell signaling; cyclooxygenase vanadium; tyrosine phosphatase; cell signaling; cyclooxygenase
Show Figures

Figure 1

MDPI and ACS Style

Korbecki, J.; Baranowska-Bosiacka, I.; Gutowska, I.; Chlubek, D. Vanadium Compounds as Pro-Inflammatory Agents: Effects on Cyclooxygenases. Int. J. Mol. Sci. 2015, 16, 12648-12668.

Show more citation formats Show less citations formats

Article Access Map

Only visits after 24 November 2015 are recorded.
Back to TopTop