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Int. J. Mol. Sci. 2015, 16(6), 12531-12546;

25-Hydroxyvitamin D3 Levels, BsmI Polymorphism and Insulin Resistance in Brazilian Amazonian Children

Department of Nutrition, School of Public Health, University of São Paulo, Avenida Dr. Arnaldo 715, CEP 01246-904 São Paulo, Brazil
Author to whom correspondence should be addressed.
Academic Editor: Lu Qi
Received: 15 April 2015 / Revised: 12 May 2015 / Accepted: 18 May 2015 / Published: 3 June 2015
(This article belongs to the Special Issue Gene-Nutrient Interactions)
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Vitamin D is associated with a wide range of other functions beyond bone development. We evaluated the factors associated with 25-hydroxyvitamin D levels in 974 children aged ≤10 years and the impact of BsmI polymorphism of the vitamin D receptor (VDR) gene (rs1544410) on metabolic parameters in a subsample (n: 430) with a follow-up 2 years later from the initial population-based cross-sectional study. Multiple linear regression models were used in the analyses. The prevalence (95% CI) of vitamin D deficiency, insufficiency and sufficiency of children was 11.1% (9.2–13.2), 21.8% (19.2–24.5) and 67.2% (64.1–70.1), respectively. Overall, 23% of the variation in serum 25-hydroxyvitamin D concentrations was accounted for by BsmI polymorphism β = −0.053 (95% CI) (−0.100, −0.006), maternal schooling (≥9 years) β = 0.100 (0.039, 0.161), serum vitamin E β = 0.478 (0.381, 0.574), total cholesterol concentration β = 0.232 (0.072, 0.393) and serum folate β = 0.064 (0.013, 0.115). BsmI polymorphism was positively associated with HOMA-IR β = 0.122 (0.002, 0.243) and fasting glucose concentration β = 1.696 (0.259, 3.133). In conclusion, variables related to socioeconomic level, the presence of the allele risk for BsmI and other nutrient concentrations were associated with serum 25-hydroxyvitamin D concentrations. Our results suggest that BsmI polymorphism is correlated with metabolic outcomes. View Full-Text
Keywords: vitamin D; genetic polymorphism; children; nutrition; insulin resistance vitamin D; genetic polymorphism; children; nutrition; insulin resistance
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Cobayashi, F.; Lourenço, B.H.; Cardoso, M.A. 25-Hydroxyvitamin D3 Levels, BsmI Polymorphism and Insulin Resistance in Brazilian Amazonian Children. Int. J. Mol. Sci. 2015, 16, 12531-12546.

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