Next Article in Journal
Mesenchymal Stem Cells and Induced Pluripotent Stem Cells as Therapies for Multiple Sclerosis
Next Article in Special Issue
Sasa quelpaertensis Leaf Extract Inhibits Colon Cancer by Regulating Cancer Cell Stemness in Vitro and in Vivo
Previous Article in Journal
Cellular Anti-Melanogenic Effects of a Euryale ferox Seed Extract Ethyl Acetate Fraction via the Lysosomal Degradation Machinery
Previous Article in Special Issue
Autophagy Induction by Silibinin Positively Contributes to Its Anti-Metastatic Capacity via AMPK/mTOR Pathway in Renal Cell Carcinoma
Open AccessReview

In Vitro and in Vivo Antitumoral Effects of Combinations of Polyphenols, or Polyphenols and Anticancer Drugs: Perspectives on Cancer Treatment

1
Department of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata", Rome 00133, Italy
2
Department of Experimental Medicine, University of Rome "Sapienza", Rome 00164, Italy
3
Dipartimento di Scienze Motorie, Umane e della Salute, Università di Roma, Foro Italico, Rome 00194, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Sanjay K. Srivastava
Int. J. Mol. Sci. 2015, 16(5), 9236-9282; https://doi.org/10.3390/ijms16059236
Received: 13 February 2015 / Revised: 9 April 2015 / Accepted: 15 April 2015 / Published: 24 April 2015
(This article belongs to the Special Issue Bioactive Phytochemicals in Functional Foods for Cancer Prevention)
Carcinogenesis is a multistep process triggered by genetic alterations that activate different signal transduction pathways and cause the progressive transformation of a normal cell into a cancer cell. Polyphenols, compounds ubiquitously expressed in plants, have anti-inflammatory, antimicrobial, antiviral, anticancer, and immunomodulatory properties, all of which are beneficial to human health. Due to their ability to modulate the activity of multiple targets involved in carcinogenesis through direct interaction or modulation of gene expression, polyphenols can be employed to inhibit the growth of cancer cells. However, the main problem related to the use of polyphenols as anticancer agents is their poor bioavailability, which might hinder the in vivo effects of the single compound. In fact, polyphenols have a poor absorption and biodistribution, but also a fast metabolism and excretion in the human body. The poor bioavailability of a polyphenol will affect the effective dose delivered to cancer cells. One way to counteract this drawback could be combination treatment with different polyphenols or with polyphenols and other anti-cancer drugs, which can lead to more effective antitumor effects than treatment using only one of the compounds. This report reviews current knowledge on the anticancer effects of combinations of polyphenols or polyphenols and anticancer drugs, with a focus on their ability to modulate multiple signaling transduction pathways involved in cancer. View Full-Text
Keywords: polyphenols; bioavailability; carcinogenesis; anticancer drugs; nanotechnology polyphenols; bioavailability; carcinogenesis; anticancer drugs; nanotechnology
Show Figures

Figure 1

MDPI and ACS Style

Fantini, M.; Benvenuto, M.; Masuelli, L.; Frajese, G.V.; Tresoldi, I.; Modesti, A.; Bei, R. In Vitro and in Vivo Antitumoral Effects of Combinations of Polyphenols, or Polyphenols and Anticancer Drugs: Perspectives on Cancer Treatment. Int. J. Mol. Sci. 2015, 16, 9236-9282. https://doi.org/10.3390/ijms16059236

AMA Style

Fantini M, Benvenuto M, Masuelli L, Frajese GV, Tresoldi I, Modesti A, Bei R. In Vitro and in Vivo Antitumoral Effects of Combinations of Polyphenols, or Polyphenols and Anticancer Drugs: Perspectives on Cancer Treatment. International Journal of Molecular Sciences. 2015; 16(5):9236-9282. https://doi.org/10.3390/ijms16059236

Chicago/Turabian Style

Fantini, Massimo; Benvenuto, Monica; Masuelli, Laura; Frajese, Giovanni V.; Tresoldi, Ilaria; Modesti, Andrea; Bei, Roberto. 2015. "In Vitro and in Vivo Antitumoral Effects of Combinations of Polyphenols, or Polyphenols and Anticancer Drugs: Perspectives on Cancer Treatment" Int. J. Mol. Sci. 16, no. 5: 9236-9282. https://doi.org/10.3390/ijms16059236

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop