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Open AccessReview

Iron Oxide Nanoparticles for Magnetically-Guided and Magnetically-Responsive Drug Delivery

1
Departament de Fisicoquímica; Facultat de Farmàcia; Institut de Nanociència i Nanotecnologia (IN2UB), Universitat de Barcelona, 08028 Barcelona, Catalonia, Spain
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Departament de Farmàcia i Tecnologia Farmacèutica, Facultat de Farmàcia, Institut de Nanociència i Nanotecnologia (IN2UB), Universitat de Barcelona, 08028 Barcelona, Catalonia, Spain
3
Departament de Fisiologia, Facultat de Farmàcia; Institut de Nanociència i Nanotecnologia (IN2UB), Universitat de Barcelona, 08028 Barcelona, Catalonia, Spain
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Author to whom correspondence should be addressed.
Academic Editor: O. Thompson Mefford
Int. J. Mol. Sci. 2015, 16(4), 8070-8101; https://doi.org/10.3390/ijms16048070
Received: 4 March 2015 / Revised: 27 March 2015 / Accepted: 3 April 2015 / Published: 10 April 2015
(This article belongs to the Special Issue Magnetic Nanoparticles 2015)
In this review, we discuss the recent advances in and problems with the use of magnetically-guided and magnetically-responsive nanoparticles in drug delivery and magnetofection. In magnetically-guided nanoparticles, a constant external magnetic field is used to transport magnetic nanoparticles loaded with drugs to a specific site within the body or to increase the transfection capacity. Magnetofection is the delivery of nucleic acids under the influence of a magnetic field acting on nucleic acid vectors that are associated with magnetic nanoparticles. In magnetically-responsive nanoparticles, magnetic nanoparticles are encapsulated or embedded in a larger colloidal structure that carries a drug. In this last case, an alternating magnetic field can modify the structure of the colloid, thereby providing spatial and temporal control over drug release. View Full-Text
Keywords: magnetic nanoparticles; magnetoliposomes; liposomes; gels; nanotechnology; controlled release; chemotherapy magnetic nanoparticles; magnetoliposomes; liposomes; gels; nanotechnology; controlled release; chemotherapy
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MDPI and ACS Style

Estelrich, J.; Escribano, E.; Queralt, J.; Busquets, M.A. Iron Oxide Nanoparticles for Magnetically-Guided and Magnetically-Responsive Drug Delivery. Int. J. Mol. Sci. 2015, 16, 8070-8101.

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