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Int. J. Mol. Sci. 2015, 16(4), 7796-7801;

Inflammatory Biomarkers as Differential Predictors of Antidepressant Response

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1-8-1 Inohana, Chiba 260-7680, Japan
Academic Editor: Cesar Borlongan
Received: 10 March 2015 / Revised: 3 April 2015 / Accepted: 6 April 2015 / Published: 8 April 2015
Full-Text   |   PDF [806 KB, uploaded 8 April 2015]   |  


Although antidepressants are generally effective in the treatment of major depressive disorder (MDD), it can still take weeks before patients feel the full antidepressant effects. Despite the efficacy of standard treatments, approximately two-thirds of patients with MDD fail to respond to pharmacotherapy. Therefore, the identification of blood biomarkers that can predict the treatment response to antidepressants would be highly useful in order to improve this situation. This article discusses inflammatory molecules as predictive biomarkers for antidepressant responses to several classes of antidepressants, including the N-methyl-d-aspartate (NMDA) receptor antagonist ketamine. View Full-Text
Keywords: antidepressant; biomarker; cytokine; inflammation; ketamine; predictor; response antidepressant; biomarker; cytokine; inflammation; ketamine; predictor; response

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Hashimoto, K. Inflammatory Biomarkers as Differential Predictors of Antidepressant Response. Int. J. Mol. Sci. 2015, 16, 7796-7801.

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