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Int. J. Mol. Sci. 2015, 16(3), 4800-4813;

Extracellular Vesicles in Alzheimer’s Disease: Friends or Foes? Focus on Aβ-Vesicle Interaction

CNR Institute of Neuroscience, via Vanvitelli 32, 20129 Milano, Italy
Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy
Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, via Olgettina 60, 20132 Milano, Italy
IRCCS Humanitas, via Manzoni 56, 20089 Rozzano, Italy
Author to whom correspondence should be addressed.
Academic Editor: G. Jean Harry
Received: 23 December 2014 / Revised: 16 February 2015 / Accepted: 17 February 2015 / Published: 3 March 2015
(This article belongs to the Special Issue Molecular Research in Neurotoxicology)
Full-Text   |   PDF [1133 KB, uploaded 3 March 2015]   |  


The intercellular transfer of amyloid-β (Aβ) and tau proteins has received increasing attention in Alzheimer’s disease (AD). Among other transfer modes, Aβ and tau dissemination has been suggested to occur through release of Extracellular Vesicles (EVs), which may facilitate delivery of pathogenic proteins over large distances. Recent evidence indicates that EVs carry on their surface, specific molecules which bind to extracellular Aβ, opening the possibility that EVs may also influence Aβ assembly and synaptotoxicity. In this review we focus on studies which investigated the impact of EVs in Aβ-mediated neurodegeneration and showed either detrimental or protective role for EVs in the pathology. View Full-Text
Keywords: Extracellular Vesicles; Aβ assembly; neurodegeneration; oligomeric Aβ; toxcicity Extracellular Vesicles; Aβ assembly; neurodegeneration; oligomeric Aβ; toxcicity

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Joshi, P.; Benussi, L.; Furlan, R.; Ghidoni, R.; Verderio, C. Extracellular Vesicles in Alzheimer’s Disease: Friends or Foes? Focus on Aβ-Vesicle Interaction. Int. J. Mol. Sci. 2015, 16, 4800-4813.

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