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Int. J. Mol. Sci. 2015, 16(2), 3970-3979;

Regulation of Translation Factor EEF1D Gene Function by Alternative Splicing

Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan
Department of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa 903-0215, Japan
Author to whom correspondence should be addressed.
Academic Editor: Akila Mayeda
Received: 19 December 2014 / Accepted: 4 February 2015 / Published: 12 February 2015
(This article belongs to the Special Issue Pre-mRNA Splicing)
Full-Text   |   PDF [930 KB, uploaded 12 February 2015]   |  


Alternative splicing is an exquisite mechanism that allows one coding gene to have multiple functions. The alternative splicing machinery is necessary for proper development, differentiation and stress responses in a variety of organisms, and disruption of this machinery is often implicated in human diseases. Previously, we discovered a long form of eukaryotic elongation factor 1Bδ (eEF1Bδ; this long-form eEF1Bδ results from alternative splicing of EEF1D transcripts and regulates the cellular stress response by transcriptional activation, not translational enhancement, of heat-shock responsive genes. In this review, we discuss the molecular function of EEF1D alternative splicing products and the estimated implication of human diseases. View Full-Text
Keywords: elongation factor; alternative splicing; heat shock; stress response elongation factor; alternative splicing; heat shock; stress response

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Kaitsuka, T.; Matsushita, M. Regulation of Translation Factor EEF1D Gene Function by Alternative Splicing. Int. J. Mol. Sci. 2015, 16, 3970-3979.

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