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A Time to Kill: Targeting Apoptosis in Cancer

Department of Hematology and Medical Oncology at the Winship Cancer Institute of Emory University, Atlanta, GA 30322, USA
Author to whom correspondence should be addressed.
Academic Editors: Anthony Lemarié and Alan Leonard
Int. J. Mol. Sci. 2015, 16(2), 2942-2955;
Received: 12 December 2014 / Revised: 8 January 2015 / Accepted: 23 January 2015 / Published: 28 January 2015
(This article belongs to the Collection Programmed Cell Death and Apoptosis)
PDF [1001 KB, uploaded 28 January 2015]


The process of apoptosis is essential for maintaining the physiologic balance between cell death and cell growth. This complex process is executed by two major pathways that participate in activating an executioner mechanism leading to chromatin disintegration and nuclear fragmentation. Dysregulation of these pathways often contributes to cancer development and resistance to cancer therapy. Here, we review the most recent discoveries in apoptosis regulation and possible mechanisms for resensitizing tumor cells to therapy. View Full-Text
Keywords: targeting apoptosis; cancer targeting apoptosis; cancer

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Koff, J.L.; Ramachandiran, S.; Bernal-Mizrachi, L. A Time to Kill: Targeting Apoptosis in Cancer. Int. J. Mol. Sci. 2015, 16, 2942-2955.

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