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Int. J. Mol. Sci. 2015, 16(2), 2913-2941;

Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium Eriobotryae

Key laboratory of Industrial Ecology and Environmental Engineering (MOE), Faculty of Chemical, Environmental and Biological Science and Technology, Dalian University of Technology, Dalian 116024, China
System Biology Lab, University of Florida, Gainesville, FL 32608, USA
Department of Electrical and Computer Engineering, University of Florida, Gainesville, FL 32608, USA
School of Chemistry and Environmental Engineering, Hubei University for Nationalities, Enshi 445000, China
Center of Bioinformatics, College of Life Science, Northwest A&F University, Yangling 712100, China
Lab of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editor: Vladimír Křen
Received: 13 November 2014 / Accepted: 22 January 2015 / Published: 28 January 2015
(This article belongs to the Section Biochemistry)
Full-Text   |   PDF [4407 KB, uploaded 6 February 2015]   |  


Inflammation is a hallmark of many diseases like diabetes, cancers, atherosclerosis and arthritis. Thus, lots of concerns have been raised toward developing novel anti-inflammatory agents. Many alternative herbal medicines possess excellent anti-inflammatory properties, yet their precise mechanisms of action are yet to be elucidated. Here, a novel systems pharmacology approach based on a large number of chemical, biological and pharmacological data was developed and exemplified by a probe herb Folium Eriobotryae, a widely used clinical anti-inflammatory botanic drug. The results show that 11 ingredients of this herb with favorable pharmacokinetic properties are predicted as active compounds for anti-inflammatory treatment. In addition, via systematic network analyses, their targets are identified to be 43 inflammation-associated proteins including especially COX2, ALOX5, PPARG, TNF and RELA that are mainly involved in the mitogen-activated protein kinase (MAPK) signaling pathway, the rheumatoid arthritis pathway and NF-κB signaling pathway. All these demonstrate that the integrated systems pharmacology method provides not only an effective tool to illustrate the anti-inflammatory mechanisms of herbs, but also a new systems-based approach for drug discovery from, but not limited to, herbs, especially when combined with further experimental validations. View Full-Text
Keywords: systems pharmacology; herbal medicine; anti-inflammation; Folium Eriobotryae systems pharmacology; herbal medicine; anti-inflammation; Folium Eriobotryae

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Zhang, J.; Li, Y.; Chen, S.-S.; Zhang, L.; Wang, J.; Yang, Y.; Zhang, S.; Pan, Y.; Wang, Y.; Yang, L. Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium Eriobotryae. Int. J. Mol. Sci. 2015, 16, 2913-2941.

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