Next Article in Journal
Autophagy in DNA Damage Response
Next Article in Special Issue
Anti-TMV Activity of Malformin A1, a Cyclic Penta-Peptide Produced by an Endophytic Fungus Aspergillus tubingensis FJBJ11
Previous Article in Journal / Special Issue
Insight into the Molecular and Functional Diversity of Cnidarian Neuropeptides
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 16
Issue 2
10.3390/ijms16022626
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Fatal Attraction: How Bacterial Adhesins Affect Host Signaling and What We Can Learn from Them

by
Daniel H. Stones
and
Anne-Marie Krachler
*
Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2015, 16(2), 2626-2640; https://doi.org/10.3390/ijms16022626
Submission received: 27 November 2014 / Revised: 25 December 2014 / Accepted: 19 January 2015 / Published: 23 January 2015
(This article belongs to the Special Issue Bioactive Carbohydrates and Peptides)
Browse Figure
Versions Notes

Abstract

The ability of bacterial species to colonize and infect host organisms is critically dependent upon their capacity to adhere to cellular surfaces of the host. Adherence to cell surfaces is known to be essential for the activation and delivery of certain virulence factors, but can also directly affect host cell signaling to aid bacterial spread and survival. In this review we will discuss the recent advances in the field of bacterial adhesion, how we are beginning to unravel the effects adhesins have on host cell signaling, and how these changes aid the bacteria in terms of their survival and evasion of immune responses. Finally, we will highlight how the exploitation of bacterial adhesins may provide new therapeutic avenues for the treatment of a wide range of bacterial infections.
Keywords: adhesion; adhesin; cell-signaling; host–pathogen interaction; bacterial attachment; anti-adhesion therapy adhesion; adhesin; cell-signaling; host–pathogen interaction; bacterial attachment; anti-adhesion therapy

Share and Cite

MDPI and ACS Style

Stones, D.H.; Krachler, A.-M. Fatal Attraction: How Bacterial Adhesins Affect Host Signaling and What We Can Learn from Them. Int. J. Mol. Sci. 2015, 16, 2626-2640. https://doi.org/10.3390/ijms16022626

AMA Style

Stones DH, Krachler A-M. Fatal Attraction: How Bacterial Adhesins Affect Host Signaling and What We Can Learn from Them. International Journal of Molecular Sciences. 2015; 16(2):2626-2640. https://doi.org/10.3390/ijms16022626

Chicago/Turabian Style

Stones, Daniel H., and Anne-Marie Krachler. 2015. "Fatal Attraction: How Bacterial Adhesins Affect Host Signaling and What We Can Learn from Them" International Journal of Molecular Sciences 16, no. 2: 2626-2640. https://doi.org/10.3390/ijms16022626

APA Style

Stones, D. H., & Krachler, A.-M. (2015). Fatal Attraction: How Bacterial Adhesins Affect Host Signaling and What We Can Learn from Them. International Journal of Molecular Sciences, 16(2), 2626-2640. https://doi.org/10.3390/ijms16022626

Article Metrics

Back to TopTop