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Int. J. Mol. Sci. 2015, 16(12), 29574-29582;

Synthesis and Evaluation of Neuroprotective Selenoflavanones

College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, Korea
Office of Research Affairs, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03720, Korea
College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02453, Korea
Author to whom correspondence should be addressed.
Academic Editor: Katalin Prokai-Tatrai
Received: 1 November 2015 / Revised: 30 November 2015 / Accepted: 4 December 2015 / Published: 10 December 2015
(This article belongs to the Collection Neuroprotective Strategies)
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The physicochemical properties and antioxidant activity of a molecule could be improved by the substitution of an oxygen atom in a molecule with selenium. We synthesized selenoflavanones and flavanones to evaluate their neuroprotective effects. The selenoflavanones showed improved physicochemical properties, suggestive of the ability to pass through the blood-brain barrier (BBB). They showed in vitro antioxidant effects against hydrogen peroxide, and did not result in severe cytotoxicity. Moreover, infarction volumes in a transient ischemia mouse model were significantly reduced by the selenoflavanone treatments. View Full-Text
Keywords: selenoflavanone; flavanone; selenium; neuroprotect; antioxidant; blood-brain barrier (BBB) selenoflavanone; flavanone; selenium; neuroprotect; antioxidant; blood-brain barrier (BBB)

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Choi, Y.-S.; Kim, D.-M.; Kim, Y.-J.; Yang, S.; Lee, K.-T.; Ryu, J.H.; Jeong, J.-H. Synthesis and Evaluation of Neuroprotective Selenoflavanones. Int. J. Mol. Sci. 2015, 16, 29574-29582.

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