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Open AccessArticle

Increased ARPP-19 Expression Is Associated with Hepatocellular Carcinoma

1
Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
2
Liver Cancer Institute of Zhongshan Hospital, Fudan University, Shanghai 200032, China
3
Department of Oncology and Institute of Traditional Chinese Medicine in Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
4
Department of Biochemistry, Microbiology and Immunology, Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON K1H 8M5, Canada
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Johannes Haybaeck
Int. J. Mol. Sci. 2015, 16(1), 178-192; https://doi.org/10.3390/ijms16010178
Received: 7 October 2014 / Accepted: 15 December 2014 / Published: 24 December 2014
(This article belongs to the Collection Molecular Mechanisms of Human Liver Diseases)
The cAMP-regulated phosphoprotein 19 (ARPP-19) plays a key role in cell mitotic G2/M transition. Expression of ARPP-19 was increased in human hepatocellular carcinoma (HCC) compared to adjacent non-tumorous liver tissues in 36 paired liver samples, and the level of ARPP-19 in HCC tissues was positively correlated with the tumor size. To determine the interrelationship between ARPP-19 expression and HCC, we silenced ARPP-19 expression in the human hepatocarcinoma HepG2 and SMMC-7721 cells using lentivirus encoding ARPP-19 siRNA. HepG2 and SMMC-7721 cells with ARPP-19 knockdown displayed lowered cell growth rate, retarded colony formation and increased arrest at the G2/M phase transition. Silencing ARPP-19 in HCC cells resulted in decreased protein levels of phospho-(Ser) CDKs substrates and increased levels of inactivated cyclin division cycle 2 (Cdc2). Therefore, ARPP-19 may play a role in HCC pathogenesis through regulating cell proliferation. View Full-Text
Keywords: hepatocellular carcinoma; ARPP-19; cell proliferation; cell cycle hepatocellular carcinoma; ARPP-19; cell proliferation; cell cycle
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Song, H.; Pan, J.; Liu, Y.; Wen, H.; Wang, L.; Cui, J.; Liu, Y.; Hu, B.; Yao, Z.; Ji, G. Increased ARPP-19 Expression Is Associated with Hepatocellular Carcinoma. Int. J. Mol. Sci. 2015, 16, 178-192.

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