Oxidative Stress and Its Significant Roles in Neurodegenerative Diseases and Cancer
Abstract
:1. Introduction
2. Oxidative Damage to Lipids
2.1. Lipid Peroxidation
2.2. Oxysterols
3. Oxidative Damage to Protein
Carbonyl Protein as a Potential Oxidative Damage Biomarker
4. Oxidative Damage to DNA
4.1. DNA Damage Formation from Oxidative Modification
4.2. DNA Damage Formation from Nitrative Modification
4.3. 8-OxodG and 8-Nitroguanine Are Potential Mutagenic DNA Lesions
5. Oxidative Stress and Neurodegenerative Diseases
5.1. Lipid Oxidation in Neurodegenerative Diseases
5.2. Carbonyl Protein in Neurodegenerative Diseases
5.3. DNA Damage in Neurodegenerative Diseases
6. Oxidative Stress and Cancers
6.1. Lipid Oxidation in Cancers
6.2. Carbonyl Protein in Cancers
6.3. DNA Damage in Inflammation-Related Cancers
6.3.1. DNA Damage in Parasite-Associated Cancers
6.3.2. DNA Damage in Bacterial and Viral Infection-Related Cancers
6.3.3. DNA Damage in Inflammation-Related Diseases and Cancers
6.4. DNA Damage in Stemness Cells of Inflammation-Related Cancers
6.5. Oxidative Stress and DNA Methylation
7. Conclusions: Oxidative Stress and Its Significant Roles in Neurodegenerative Diseases and Cancer
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Thanan, R.; Oikawa, S.; Hiraku, Y.; Ohnishi, S.; Ma, N.; Pinlaor, S.; Yongvanit, P.; Kawanishi, S.; Murata, M. Oxidative Stress and Its Significant Roles in Neurodegenerative Diseases and Cancer. Int. J. Mol. Sci. 2015, 16, 193-217. https://doi.org/10.3390/ijms16010193
Thanan R, Oikawa S, Hiraku Y, Ohnishi S, Ma N, Pinlaor S, Yongvanit P, Kawanishi S, Murata M. Oxidative Stress and Its Significant Roles in Neurodegenerative Diseases and Cancer. International Journal of Molecular Sciences. 2015; 16(1):193-217. https://doi.org/10.3390/ijms16010193
Chicago/Turabian StyleThanan, Raynoo, Shinji Oikawa, Yusuke Hiraku, Shiho Ohnishi, Ning Ma, Somchai Pinlaor, Puangrat Yongvanit, Shosuke Kawanishi, and Mariko Murata. 2015. "Oxidative Stress and Its Significant Roles in Neurodegenerative Diseases and Cancer" International Journal of Molecular Sciences 16, no. 1: 193-217. https://doi.org/10.3390/ijms16010193