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Int. J. Mol. Sci. 2014, 15(8), 14574-14590;

Liquid Phase Sintered Ceramic Bone Scaffolds by Combined Laser and Furnace

State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China
Department of Spine Surgery, the Second Xiangya Hospital of Central South University, Changsha 410011, China
Shenzhen Research Institute, Central South University, Shenzhen 518057, China
Cancer Research Institute, Central South University, Changsha 410078, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 26 June 2014 / Revised: 29 July 2014 / Accepted: 14 August 2014 / Published: 21 August 2014
(This article belongs to the Special Issue Artificial Organs)
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Fabrication of mechanically competent bioactive scaffolds is a great challenge in bone tissue engineering. In this paper, β-tricalcium phosphate (β-TCP) scaffolds were successfully fabricated by selective laser sintering combined with furnace sintering. Bioglass 45S5 was introduced in the process as liquid phase in order to improve the mechanical and biological properties. The results showed that sintering of β-TCP with the bioglass revealed some features of liquid phase sintering. The optimum amount of 45S5 was 5 wt %. At this point, the scaffolds were densified without defects. The fracture toughness, compressive strength and stiffness were 1.67 MPam1/2, 21.32 MPa and 264.32 MPa, respectively. Bone like apatite layer was formed and the stimulation for apatite formation was increased with increase in 45S5 content after soaking in simulated body fluid, which indicated that 45S5 could improve the bioactivity. Furthermore, MG-63 cells adhered and spread well, and proliferated with increase in the culture time. View Full-Text
Keywords: bone scaffolds; liquid phase; 45S5; mechanical properties; bioactivity bone scaffolds; liquid phase; 45S5; mechanical properties; bioactivity

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Feng, P.; Deng, Y.; Duan, S.; Gao, C.; Shuai, C.; Peng, S. Liquid Phase Sintered Ceramic Bone Scaffolds by Combined Laser and Furnace. Int. J. Mol. Sci. 2014, 15, 14574-14590.

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