Next Article in Journal
Cloning and Expression Characteristics of the Pig Stra8 Gene
Previous Article in Journal
Copy Number Analysis of 24 Oncogenes: MDM4 Identified as a Putative Marker for Low Recurrence Risk in Non Muscle Invasive Bladder Cancer
Article

Ficus carica Polysaccharides Promote the Maturation and Function of Dendritic Cells

1
Department of Laboratory Medicine, the Affiliated People's Hospital, Jiangsu University, Zhenjiang 212002, China
2
School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang 212013, China
3
School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China
4
Department of Pathology and Centre of Infection and Immunology, the University of Hong Kong, Hong Kong 999077, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2014, 15(7), 12469-12479; https://doi.org/10.3390/ijms150712469
Received: 18 December 2013 / Revised: 25 February 2014 / Accepted: 20 March 2014 / Published: 14 July 2014
(This article belongs to the Section Biochemistry)
Various polysaccharides purified from plants are considered to be biological response modifiers and have been shown to enhance immune responses. Ficus carica L. is a Chinese traditional plant and has been widely used in Asian countries for its anti-tumor properties. Ficus carica polysaccharides (FCPS), one of the most essential and effective components in Ficus carica L., have been considered to be a beneficial immunomodulator and may be used in immunotherapy. However, the immunologic mechanism of FCPS is still unclear. Dectin-1 is a non-toll-like pattern recognition receptor, predominately expressed on dendritic cells (DCs). Activation of DCs through dectin-1 signaling can lead to the maturation of DC, thus inducing both innate and adaptive immune responses against tumor development and microbial infection. In our study, we found that FCPS could effectively stimulate DCs, partially through the dectin-1/Syk pathway, and promote their maturation, as shown by the up-regulation of CD40, CD80, CD86, and major histocompatibility complex II (MHCII). FCPS also enhanced the production of cytokines by DCs, including IL-12, IFN-γ, IL-6, and IL-23. Moreover, FCPS-treated DCs showed an enhanced capability to stimulate T cells and promote T cell proliferation. Altogether, these results demonstrate that FCPS are able to activate and maturate DCs, thereby up-regulating the immunostimulatory capacity of DCs, which leads to enhanced T cell responses. View Full-Text
Keywords: polysaccharide; dendritic cells; dectin-1; Syk; immunomodulators polysaccharide; dendritic cells; dectin-1; Syk; immunomodulators
Show Figures

Figure 1

MDPI and ACS Style

Tian, J.; Zhang, Y.; Yang, X.; Rui, K.; Tang, X.; Ma, J.; Chen, J.; Xu, H.; Lu, L.; Wang, S. Ficus carica Polysaccharides Promote the Maturation and Function of Dendritic Cells. Int. J. Mol. Sci. 2014, 15, 12469-12479. https://doi.org/10.3390/ijms150712469

AMA Style

Tian J, Zhang Y, Yang X, Rui K, Tang X, Ma J, Chen J, Xu H, Lu L, Wang S. Ficus carica Polysaccharides Promote the Maturation and Function of Dendritic Cells. International Journal of Molecular Sciences. 2014; 15(7):12469-12479. https://doi.org/10.3390/ijms150712469

Chicago/Turabian Style

Tian, Jie, Yue Zhang, Xiaomin Yang, Ke Rui, Xinyi Tang, Jie Ma, Jianguo Chen, Huaxi Xu, Liwei Lu, and Shengjun Wang. 2014. "Ficus carica Polysaccharides Promote the Maturation and Function of Dendritic Cells" International Journal of Molecular Sciences 15, no. 7: 12469-12479. https://doi.org/10.3390/ijms150712469

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop