Next Article in Journal
Genetic Variation of the Endangered Gentiana lutea L. var. aurantiaca (Gentianaceae) in Populations from the Northwest Iberian Peninsula
Next Article in Special Issue
Rapamycin-Induced Apoptosis in HGF-Stimulated Lens Epithelial Cells by AKT/mTOR, ERK and JAK2/STAT3 Pathways
Previous Article in Journal
A New Criterion to Evaluate Water Vapor Interference in Protein Secondary Structural Analysis by FTIR Spectroscopy
Previous Article in Special Issue
Apoptotic Death of Cancer Stem Cells for Cancer Therapy

Cytotoxic Autophagy in Cancer Therapy

Department of Pharmacology and Toxicology, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2014, 15(6), 10034-10051;
Received: 3 April 2014 / Revised: 17 April 2014 / Accepted: 19 May 2014 / Published: 5 June 2014
(This article belongs to the Collection Programmed Cell Death and Apoptosis)
Autophagy is a process of cellular self-digestion, whereby the cell degrades subcellular materials in order to generate energy and metabolic precursors in order to prolong survival, classically under conditions of nutrient deprivation. Autophagy can also involve the degradation of damaged or aged organelles, and misfolded or damaged proteins to eliminate these components that might otherwise be deleterious to cellular survival. Consequently, autophagy has generally been considered a prosurvival response. Many, if not most chemotherapeutic drugs and radiation also promote autophagy, which is generally considered a cytoprotective response, in that its inhibition frequently promotes apoptotic cells death. Furthermore, it has been shown that conventional chemotherapeutic drugs and radiation alone rarely induce a form of autophagy that leads to cell death. However, there are multiple examples in the literature where newer chemotherapeutic agents, drug combinations or drugs in combination with radiation promote autophagic cell death. This review will describe autophagic cell death induced in breast tumor cells, lung cancer cells as well as glioblastoma, demonstrating that it cannot be concluded that stress induced autophagy is, of necessity, cytoprotective in function. View Full-Text
Keywords: autophagy; apoptosis; radiation; chemotherapy autophagy; apoptosis; radiation; chemotherapy
Show Figures

Figure 1

MDPI and ACS Style

Sharma, K.; Le, N.; Alotaibi, M.; Gewirtz, D.A. Cytotoxic Autophagy in Cancer Therapy. Int. J. Mol. Sci. 2014, 15, 10034-10051.

AMA Style

Sharma K, Le N, Alotaibi M, Gewirtz DA. Cytotoxic Autophagy in Cancer Therapy. International Journal of Molecular Sciences. 2014; 15(6):10034-10051.

Chicago/Turabian Style

Sharma, Khushboo, Ngoc Le, Moureq Alotaibi, and David A. Gewirtz. 2014. "Cytotoxic Autophagy in Cancer Therapy" International Journal of Molecular Sciences 15, no. 6: 10034-10051.

Find Other Styles

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Back to TopTop