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Int. J. Mol. Sci. 2014, 15(5), 8713-8742;

Role of Mitochondria in Nonalcoholic Fatty Liver Disease

Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Missouri, Columbia, MO 65212, USA
Author to whom correspondence should be addressed.
Received: 4 March 2014 / Revised: 4 May 2014 / Accepted: 7 May 2014 / Published: 15 May 2014
(This article belongs to the Collection Molecular Mechanisms of Human Liver Diseases)
Full-Text   |   PDF [384 KB, uploaded 19 June 2014]


Nonalcoholic fatty liver disease (NAFLD) affects about 30% of the general population in the United States and includes a spectrum of disease that includes simple steatosis, non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis. Significant insight has been gained into our understanding of the pathogenesis of NALFD; however the key metabolic aberrations underlying lipid accumulation in hepatocytes and the progression of NAFLD remain to be elucidated. Accumulating and emerging evidence indicate that hepatic mitochondria play a critical role in the development and pathogenesis of steatosis and NAFLD. Here, we review studies that document a link between the pathogenesis of NAFLD and hepatic mitochondrial dysfunction with particular focus on new insights into the role of impaired fatty acid oxidation, the transcription factor peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), and sirtuins in development and progression of NAFLD. View Full-Text
Keywords: NAFLD; NASH; mitochondria; liver; steatosis; fatty acid oxidation; PGC-1α; sirtuin-1 (SIRT1); sirtuin-3 (SIRT3) NAFLD; NASH; mitochondria; liver; steatosis; fatty acid oxidation; PGC-1α; sirtuin-1 (SIRT1); sirtuin-3 (SIRT3)
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Nassir, F.; Ibdah, J.A. Role of Mitochondria in Nonalcoholic Fatty Liver Disease. Int. J. Mol. Sci. 2014, 15, 8713-8742.

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