Next Article in Journal
Notes on the Epidemiology of Multiple Sclerosis, with Special Reference to Dietary Habits
Previous Article in Journal
HBx Protein Promotes Oval Cell Proliferation by Up-Regulation of Cyclin D1 via Activation of the MEK/ERK and PI3K/Akt Pathways
Article Menu

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2014, 15(3), 3519-3532;

Docetaxel-Loaded Chitosan Microspheres as a Lung Targeted Drug Delivery System: In Vitro and in Vivo Evaluation

Department of Thoracic surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zheng Min Road, Yangpu District, Shanghai 200433, China
Department of Thoracic surgery, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gong Wei Road, Hui Nan Town, Pudong, Shanghai 201399, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 24 December 2013 / Revised: 10 February 2014 / Accepted: 12 February 2014 / Published: 26 February 2014
(This article belongs to the Section Materials Science)
Full-Text   |   PDF [546 KB, uploaded 19 June 2014]


The aim of this study was to prepare docetaxel-loaded chitosan microspheres and to evaluate their in vitro and in vivo characteristics. Glutaraldehyde crosslinked microspheres were prepared using a water-in-oil emulsification method, and characterized in terms of the morphological examination, particle size distribution, encapsulation ratio, drug-loading coefficient and in vitro release. Pharmacokinetics and biodistribution studies were used to evaluate that microspheres have more advantage than the conventional formulations. The emulsion crosslinking method was simple to prepare microspheres and easy to scale up. The formed microspheres were spherical in shape, with a smooth surface and the size was uniform (9.6 ± 0.8 µm); the encapsulation efficiency and drug loading of prepared microspheres were 88.1% ± 3.5% and 18.7% ± 1.2%, respectively. In vitro release indicated that the DTX microspheres had a well-sustained release efficacy and in vivo studies showed that the microspheres were found to release the drug to a maximum extent in the target tissue (lung). The prepared microspheres were found to possess suitable physico-chemical properties and the particle size range. The sustained release of DTX from microspheres revealed its applicability as drug delivery system to minimize the exposure of healthy tissues while increasing the accumulation of therapeutic drug in target sites. View Full-Text
Keywords: docetaxel; microspheres; release; pharmacokinetics; biodistribution docetaxel; microspheres; release; pharmacokinetics; biodistribution
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Wang, H.; Xu, Y.; Zhou, X. Docetaxel-Loaded Chitosan Microspheres as a Lung Targeted Drug Delivery System: In Vitro and in Vivo Evaluation. Int. J. Mol. Sci. 2014, 15, 3519-3532.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top