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Int. J. Mol. Sci. 2014, 15(12), 22320-22330;

Melatonin-Induced Temporal Up-Regulation of Gene Expression Related to Ubiquitin/Proteasome System (UPS) in the Human Malaria Parasite Plasmodium falciparum

Departamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São, São Paulo 05508-900, Brazil
Departamento de Fisiologia, Instituto de Biociências, Universidade de São Paulo, São Paulo 05508-090, Brazil
Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32826, USA
Author to whom correspondence should be addressed.
Received: 25 August 2014 / Revised: 11 September 2014 / Accepted: 16 October 2014 / Published: 3 December 2014
(This article belongs to the Special Issue Advances in the Research of Melatonin 2014)
PDF [899 KB, uploaded 3 December 2014]


There is an increasing understanding that melatonin and the ubiquitin/ proteasome system (UPS) interact to regulate multiple cellular functions. Post-translational modifications such as ubiquitination are important modulators of signaling processes, cell cycle and many other cellular functions. Previously, we reported a melatonin-induced upregulation of gene expression related to ubiquitin/proteasome system (UPS) in Plasmodium falciparum, the human malaria parasite, and that P. falciparum protein kinase 7 influences this process. This implies a role of melatonin, an indolamine, in modulating intraerythrocytic development of the parasite. In this report we demonstrate by qPCR analysis, that melatonin induces gene upregulation in nine out of fourteen genes of the UPS, consisting of the same set of genes previously reported, between 4 to 5 h after melatonin treatment. We demonstrate that melatonin causes a temporally controlled gene expression of UPS members. View Full-Text
Keywords: melatonin; ubiquitin-proteasome-system; Plasmodium falciparum; malaria melatonin; ubiquitin-proteasome-system; Plasmodium falciparum; malaria

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Koyama, F.C.; Azevedo, M.F.; Budu, A.; Chakrabarti, D.; Garcia, C.R.S. Melatonin-Induced Temporal Up-Regulation of Gene Expression Related to Ubiquitin/Proteasome System (UPS) in the Human Malaria Parasite Plasmodium falciparum. Int. J. Mol. Sci. 2014, 15, 22320-22330.

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