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Int. J. Mol. Sci. 2014, 15(12), 21754-21776;

Looking into a Conceptual Framework of ROS–miRNA–Atrial Fibrillation

Institute for Bio-Medical Convergence, College of Medicine, Catholic Kwandong University, Gangneung-si, Gangwon-do 210-701, Korea
Catholic Kwandong University International St. Mary's Hospital, Incheon Metropolitan City 404-834, Korea
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 20 October 2014 / Revised: 17 November 2014 / Accepted: 19 November 2014 / Published: 26 November 2014
(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease 2015)
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Atrial fibrillation (AF) has been recognized as a major cause of cardiovascular-related morbidity and mortality. MicroRNAs (miRNAs) represent recent additions to the collection of biomolecules involved in arrhythmogenesis. Reactive oxygen species (ROS) have been independently linked to both AF and miRNA regulation. However, no attempts have been made to investigate the possibility of a framework composed of ROS–miRNA–AF that is related to arrhythmia development. Therefore, this review was designed as an attempt to offer a new approach to understanding AF pathogenesis. The aim of this review was to find and to summarize possible connections that exist among AF, miRNAs and ROS to understand the interactions among the molecular entities underlying arrhythmia development in the hopes of finding unappreciated mechanisms of AF. These findings may lead us to innovative therapies for AF, which can be a life-threatening heart condition. A systemic literature review indicated that miRNAs associated with AF might be regulated by ROS, suggesting the possibility that miRNAs translate cellular stressors, such as ROS, into AF pathogenesis. Further studies with a more appropriate experimental design to either prove or disprove the existence of an ROS–miRNA–AF framework are strongly encouraged. View Full-Text
Keywords: atrial fibrillation (AF); reactive oxygen species (ROS); miRNA; arrhythmia atrial fibrillation (AF); reactive oxygen species (ROS); miRNA; arrhythmia

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Lee, S.; Choi, E.; Cha, M.-J.; Hwang, K.-C. Looking into a Conceptual Framework of ROS–miRNA–Atrial Fibrillation. Int. J. Mol. Sci. 2014, 15, 21754-21776.

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