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Open AccessArticle

Antimicrobial Activity of Isothiocyanates from Cruciferous Plants against Methicillin-Resistant Staphylococcus aureus (MRSA)

1
Animal and Veterinary Research Centre, CECAV, University of Trás-os-Montes and Alto Douro, UTAD, Quinta de Prados, Vila Real 5000801, Portugal
2
Centre for the Research and Technology of Agro-Environmental and Biological Sciences, CITAB, University of Trás-os-Montes and Alto Douro, UTAD, Quinta de Prados, Vila Real 5000801, Portugal
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2014, 15(11), 19552-19561; https://doi.org/10.3390/ijms151119552
Received: 5 September 2014 / Revised: 21 October 2014 / Accepted: 22 October 2014 / Published: 28 October 2014
(This article belongs to the Section Biochemistry)
Purified isothiocyanates from cruciferous plants (Brassicacea, Syn. Cruciferae) plants were evaluated against 15 isolates of methicillin-resistant S. aureus isolated from diabetic foot-ulcer patients aiming the study of the potential usage of allyl-isothiocyanate, benzyl-isothiocyanate and 2-phenylethyl-isothiocyanate against this important bacteria. Disc diffusion and minimum inhibitory concentration methods were used to access the antimicrobial activity. The index (Ia) and rate (Ra) of the antibacterial activity for each compound were calculated. The results showed a highly dose-dependent compound and chemical structure antibacterial effectiveness. The results showed a strong relation between the chemical structure of isothiocyanates and its antibacterial effectiveness. The benzyl-isothiocyanate was the most effective with a minimum inhibitory concentration varying between 2.9 and 110 µg·mL−1 with an antibacterial activity rate up to 87%. Moreover, their antibacterial activity was mainly bactericidal. This study provides scientific evidence that isothiocyanates have an interesting biological value and must be considered as an important tool to be used against MRSA. View Full-Text
Keywords: chemical structure; bioactivity; antibiotic resistance; bioactive compounds chemical structure; bioactivity; antibiotic resistance; bioactive compounds
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MDPI and ACS Style

Dias, C.; Aires, A.; Saavedra, M.J. Antimicrobial Activity of Isothiocyanates from Cruciferous Plants against Methicillin-Resistant Staphylococcus aureus (MRSA). Int. J. Mol. Sci. 2014, 15, 19552-19561.

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