Next Article in Journal
In Vitro Phosphorylation Does not Influence the Aggregation Kinetics of WT α-Synuclein in Contrast to Its Phosphorylation Mutants
Next Article in Special Issue
Obesity and Its Metabolic Complications: The Role of Adipokines and the Relationship between Obesity, Inflammation, Insulin Resistance, Dyslipidemia and Nonalcoholic Fatty Liver Disease
Previous Article in Journal
Structural Characterization of the Degradation Products of a Minor Natural Sweet Diterpene Glycoside Rebaudioside M under Acidic Conditions
Previous Article in Special Issue
Meta-Omic Platforms to Assist in the Understanding of NAFLD Gut Microbiota Alterations: Tools and Applications
Article

Evaluation of Hepatic Tissue Blood Flow Using Xenon Computed Tomography with Fibrosis Progression in Nonalcoholic Fatty Liver Disease: Comparison with Chronic Hepatitis C

1
Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki 216-8511, Kanagawa, Japan
2
Shiodome Medical Examination Clinic, Tokyo 105-0013, Japan
3
Anzai Medical Co., Ltd., Tokyo 141-0033, Japan
4
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kawasaki Municipal Tama Hospital, Kawasaki 214-8525, Kanagawa, Japan
5
Division of Gastroenterology, Department of Internal Medicine, Sapporo Shirakabadai Hospital, Sapporo 062-0052, Hokkaido, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2014, 15(1), 1026-1039; https://doi.org/10.3390/ijms15011026
Received: 6 November 2013 / Revised: 24 December 2013 / Accepted: 27 December 2013 / Published: 14 January 2014
(This article belongs to the Special Issue Non-Alcoholic Fatty Liver Disease Research)
Aims: The present study evaluated the utility of xenon computed tomography (Xe-CT) as a noninvasive diagnostic procedure for the measurement of hepatic tissue blood flow (TBF) in patients with nonalcoholic fatty liver disease (NAFLD) or chronic hepatitis C (CH-C). Methods: Xe-CT was performed in 93 patients with NAFLD and in 109 patients with CH-C. Subjects were classified into one of three groups, based on fibrosis stage: group 1, no bridging fibrosis; group 2, bridging fibrosis; and group 3, liver cirrhosis. Correlations between hepatic TBFs in each fibrosis stage were examined. Results: In group 1, portal venous TBF (PVTBF), hepatic arterial (HATBF), and total hepatic TBF (THTBF) were significantly lower in patients with in nonalcoholic steatohepatitis (NASH) than in those with CH-C (p < 0.001, p < 0.05, p < 0.001, respectively). In group 2, PVTBF and THTBF were significantly lower in patients with in NASH than in those with CH-C (p < 0.001, p < 0.05, respectively). In group 3, hepatic TBFs were not significantly different when comparing patients with NASH and those with CH-C. Conclusions: PVTBF decreased due to fat infiltration. Therefore, hemodynamic changes occur relatively earlier in NAFLD than in CH-C. Patients with NASH should be monitored carefully for portal hypertensive complications in the early fibrosis stage. View Full-Text
Keywords: nonalcoholic steatohepatitis; chronic hepatitis C; hepatic tissue blood flow; Xe computed tomography nonalcoholic steatohepatitis; chronic hepatitis C; hepatic tissue blood flow; Xe computed tomography
Show Figures

MDPI and ACS Style

Shigefuku, R.; Takahashi, H.; Kato, M.; Yoshida, Y.; Suetani, K.; Noguchi, Y.; Hatsugai, M.; Nakahara, K.; Ikeda, H.; Kobayashi, M.; Matsunaga, K.; Matsumoto, N.; Okuse, C.; Itoh, F.; Maeyama, S.; Sase, S.; Suzuki, M. Evaluation of Hepatic Tissue Blood Flow Using Xenon Computed Tomography with Fibrosis Progression in Nonalcoholic Fatty Liver Disease: Comparison with Chronic Hepatitis C. Int. J. Mol. Sci. 2014, 15, 1026-1039. https://doi.org/10.3390/ijms15011026

AMA Style

Shigefuku R, Takahashi H, Kato M, Yoshida Y, Suetani K, Noguchi Y, Hatsugai M, Nakahara K, Ikeda H, Kobayashi M, Matsunaga K, Matsumoto N, Okuse C, Itoh F, Maeyama S, Sase S, Suzuki M. Evaluation of Hepatic Tissue Blood Flow Using Xenon Computed Tomography with Fibrosis Progression in Nonalcoholic Fatty Liver Disease: Comparison with Chronic Hepatitis C. International Journal of Molecular Sciences. 2014; 15(1):1026-1039. https://doi.org/10.3390/ijms15011026

Chicago/Turabian Style

Shigefuku, Ryuta, Hideaki Takahashi, Masaki Kato, Yoshihito Yoshida, Keigo Suetani, Yohei Noguchi, Moriaki Hatsugai, Kazunari Nakahara, Hiroki Ikeda, Minoru Kobayashi, Kotaro Matsunaga, Nobuyuki Matsumoto, Chiaki Okuse, Fumio Itoh, Shiro Maeyama, Shigeru Sase, and Michihiro Suzuki. 2014. "Evaluation of Hepatic Tissue Blood Flow Using Xenon Computed Tomography with Fibrosis Progression in Nonalcoholic Fatty Liver Disease: Comparison with Chronic Hepatitis C" International Journal of Molecular Sciences 15, no. 1: 1026-1039. https://doi.org/10.3390/ijms15011026

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop