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Delta Opioid Receptor and Its Peptide: A Receptor-Ligand Neuroprotection

Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL 33612, USA
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Int. J. Mol. Sci. 2013, 14(9), 17410-17419; https://doi.org/10.3390/ijms140917410
Received: 30 July 2013 / Revised: 15 August 2013 / Accepted: 19 August 2013 / Published: 23 August 2013
(This article belongs to the Special Issue Pathology and Treatment of Central Nervous System Diseases)
In pursuit of neurological therapies, the opioid system, specifically delta opioid receptors and delta opioid peptides, demonstrates promising therapeutic potential for stroke, Parkinson’s disease, and other degenerative neurological conditions. Recent studies offer strong evidence in support of the therapeutic use of delta opioid receptors, and provide insights into the underlying mechanisms of action. Delta opioid receptors have been shown to confer protective effects by mediating ionic homeostasis and activating endogenous neuroprotective pathways. Additionally, delta opioid agonists such as (D-Ala 2, D-Leu 5) enkephalin (DADLE) have been shown to decrease apoptosis and promote neuronal survival. In its entirety, the delta opioid system represents a promising target for neural therapies. View Full-Text
Keywords: stroke; delta opioid receptors; neuroprotection; DADLE; neuronal death stroke; delta opioid receptors; neuroprotection; DADLE; neuronal death
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MDPI and ACS Style

Staples, M.; Acosta, S.; Tajiri, N.; Pabon, M.; Kaneko, Y.; Borlongan, C.V. Delta Opioid Receptor and Its Peptide: A Receptor-Ligand Neuroprotection. Int. J. Mol. Sci. 2013, 14, 17410-17419. https://doi.org/10.3390/ijms140917410

AMA Style

Staples M, Acosta S, Tajiri N, Pabon M, Kaneko Y, Borlongan CV. Delta Opioid Receptor and Its Peptide: A Receptor-Ligand Neuroprotection. International Journal of Molecular Sciences. 2013; 14(9):17410-17419. https://doi.org/10.3390/ijms140917410

Chicago/Turabian Style

Staples, Meaghan; Acosta, Sandra; Tajiri, Naoki; Pabon, Mibel; Kaneko, Yuji; Borlongan, Cesar V. 2013. "Delta Opioid Receptor and Its Peptide: A Receptor-Ligand Neuroprotection" Int. J. Mol. Sci. 14, no. 9: 17410-17419. https://doi.org/10.3390/ijms140917410

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