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Open AccessArticle

Differential Proinflammatory and Oxidative Stress Response and Vulnerability to Metabolic Syndrome in Habitual High-Fat Young Male Consumers Putatively Predisposed by Their Genetic Background

1
Department of Nutrition, Food Sciences and Physiology, University of Navarra, 31008 Pamplona, Spain
2
CIBERobn Physiopathology of Obesity and Nutrition, Centre of Biomedical Research Network, 29029 Madrid, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2013, 14(9), 17238-17255; https://doi.org/10.3390/ijms140917238
Received: 3 June 2013 / Revised: 12 August 2013 / Accepted: 13 August 2013 / Published: 22 August 2013
(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
The current nutritional habits and lifestyles of modern societies favor energy overloads and a diminished physical activity, which may produce serious clinical disturbances and excessive weight gain. In order to investigate the mechanisms by which the environmental factors interact with molecular mechanisms in obesity, a pathway analysis was performed to identify genes differentially expressed in subcutaneous abdominal adipose tissue (SCAAT) from obese compared to lean male (21–35 year-old) subjects living in similar obesogenic conditions: habitual high fat dietary intake and moderate physical activity. Genes involved in inflammation (ALCAM, CTSB, C1S, YKL-40, MIF, SAA2), extracellular matrix remodeling (MMP9, PALLD), angiogenesis (EGFL6, leptin) and oxidative stress (AKR1C3, UCHL1, HSPB7 and NQO1) were upregulated; whereas apoptosis, signal transcription (CITED 2 and NR3C1), cell control and cell cycle-related genes were downregulated. Interestingly, the expression of some of these genes (C1S, SAA2, ALCAM, CTSB, YKL-40 and tenomodulin) was found to be associated with some relevant metabolic syndrome features. The obese group showed a general upregulation in the expression of inflammatory, oxidative stress, extracellular remodeling and angiogenic genes compared to lean subjects, suggesting that a given genetic background in an obesogenic environment could underlie the resistance to gaining weight and obesity-associated manifestations. View Full-Text
Keywords: metabolic syndrome; microarray; inflammation; oxidative stress; subcutaneous adipose tissue metabolic syndrome; microarray; inflammation; oxidative stress; subcutaneous adipose tissue
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MDPI and ACS Style

González-Muniesa, P.; Marrades, M.P.; Martínez, J.A.; Moreno-Aliaga, M.J. Differential Proinflammatory and Oxidative Stress Response and Vulnerability to Metabolic Syndrome in Habitual High-Fat Young Male Consumers Putatively Predisposed by Their Genetic Background. Int. J. Mol. Sci. 2013, 14, 17238-17255. https://doi.org/10.3390/ijms140917238

AMA Style

González-Muniesa P, Marrades MP, Martínez JA, Moreno-Aliaga MJ. Differential Proinflammatory and Oxidative Stress Response and Vulnerability to Metabolic Syndrome in Habitual High-Fat Young Male Consumers Putatively Predisposed by Their Genetic Background. International Journal of Molecular Sciences. 2013; 14(9):17238-17255. https://doi.org/10.3390/ijms140917238

Chicago/Turabian Style

González-Muniesa, Pedro; Marrades, María P.; Martínez, José A.; Moreno-Aliaga, María J. 2013. "Differential Proinflammatory and Oxidative Stress Response and Vulnerability to Metabolic Syndrome in Habitual High-Fat Young Male Consumers Putatively Predisposed by Their Genetic Background" Int. J. Mol. Sci. 14, no. 9: 17238-17255. https://doi.org/10.3390/ijms140917238

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