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Principles of miRNA-Target Regulation in Metazoan Models

Basic Neurosciences Division, Biomedical Research Foundation of the Academy of Athens, Soranou Efesiou 4, Athens 11527, Greece
Int. J. Mol. Sci. 2013, 14(8), 16280-16302; https://doi.org/10.3390/ijms140816280
Received: 3 June 2013 / Revised: 29 July 2013 / Accepted: 31 July 2013 / Published: 7 August 2013
(This article belongs to the Special Issue Regulation by non-coding RNAs 2013)
MicroRNAs (miRs) are key post-transcriptional regulators that silence gene expression by direct base pairing to target sites of RNAs. They have a wide variety of tissue expression patterns and are differentially expressed during development and disease. Their activity and abundance is subject to various levels of control ranging from transcription and biogenesis to miR response elements on RNAs, target cellular levels and miR turnover. This review summarizes and discusses current knowledge on the regulation of miR activity and concludes with novel non-canonical functions that have recently emerged. View Full-Text
Keywords: miR; miR biogenesis; miR targets; miR turnover; isomiR; ceRNA miR; miR biogenesis; miR targets; miR turnover; isomiR; ceRNA
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MDPI and ACS Style

Doxakis, E. Principles of miRNA-Target Regulation in Metazoan Models. Int. J. Mol. Sci. 2013, 14, 16280-16302.

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