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Volume 14
Issue 7
10.3390/ijms140713391
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Open AccessArticle

Apoferritin Modified Magnetic Particles as Doxorubicin Carriers for Anticancer Drug Delivery

by
Iva Blazkova
1,
Hoai Viet Nguyen
1,
Simona Dostalova
1,
Pavel Kopel
1,2,
Maja Stanisavljevic
1,
Marketa Vaculovicova
1,2,
Marie Stiborova
3,
Tomas Eckschlager
4,
Rene Kizek
1,2 and
Vojtech Adam
1,2,*
1
Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University in Brno, Zemedelska 1, Brno CZ-613 00, Czech Republic
2
Central European Institute of Technology, Brno University of Technology, Technicka 3058/10, Brno CZ-616 00, Czech Republic
3
Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, Prague 2 CZ-128 40, Czech Republic
4
Department of Paediatric Haematology and Oncology, 2nd Faculty of Medicine and University Hospital Motol, Charles University, V Uvalu 84, Prague 5 CZ-150 06, Czech Republic
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2013, 14(7), 13391-13402; https://doi.org/10.3390/ijms140713391
Received: 19 April 2013 / Revised: 18 May 2013 / Accepted: 23 May 2013 / Published: 27 June 2013
(This article belongs to the Special Issue Magnetic Nanoparticles 2013)
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Abstract

Magnetic particle mediated transport in combination with nanomaterial based drug carrier has a great potential for targeted cancer therapy. In this study, doxorubicin encapsulation into the apoferritin and its conjugation with magnetic particles was investigated by capillary electrophoresis with laser-induced fluorescence detection (CE-LIF). The quantification of encapsulated doxorubicin was performed by fluorescence spectroscopy and compared to CE-LIF. Moreover, the significant enhancement of the doxorubicin signal was observed by addition of methanol into the sample solution. View Full-Text
Keywords: cancer; nanomedicine; magnetic particles; doxorubicin; nanoparticles cancer; nanomedicine; magnetic particles; doxorubicin; nanoparticles
This is an open access article distributed under the Creative Commons Attribution License
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MDPI and ACS Style

Blazkova, I.; Nguyen, H.V.; Dostalova, S.; Kopel, P.; Stanisavljevic, M.; Vaculovicova, M.; Stiborova, M.; Eckschlager, T.; Kizek, R.; Adam, V. Apoferritin Modified Magnetic Particles as Doxorubicin Carriers for Anticancer Drug Delivery. Int. J. Mol. Sci. 2013, 14, 13391-13402. https://doi.org/10.3390/ijms140713391

AMA Style

Blazkova I, Nguyen HV, Dostalova S, Kopel P, Stanisavljevic M, Vaculovicova M, Stiborova M, Eckschlager T, Kizek R, Adam V. Apoferritin Modified Magnetic Particles as Doxorubicin Carriers for Anticancer Drug Delivery. International Journal of Molecular Sciences. 2013; 14(7):13391-13402. https://doi.org/10.3390/ijms140713391

Chicago/Turabian Style

Blazkova, Iva; Nguyen, Hoai V.; Dostalova, Simona; Kopel, Pavel; Stanisavljevic, Maja; Vaculovicova, Marketa; Stiborova, Marie; Eckschlager, Tomas; Kizek, Rene; Adam, Vojtech. 2013. "Apoferritin Modified Magnetic Particles as Doxorubicin Carriers for Anticancer Drug Delivery" Int. J. Mol. Sci. 14, no. 7: 13391-13402. https://doi.org/10.3390/ijms140713391

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