Int. J. Mol. Sci. 2013, 14(7), 13391-13402; https://doi.org/10.3390/ijms140713391
Apoferritin Modified Magnetic Particles as Doxorubicin Carriers for Anticancer Drug Delivery
Iva Blazkova 1, Hoai Viet Nguyen 1, Simona Dostalova 1, Pavel Kopel 1,2
, Maja Stanisavljevic 1, Marketa Vaculovicova 1,2, Marie Stiborova 3, Tomas Eckschlager 4, Rene Kizek 1,2 and Vojtech Adam 1,2,*
, Maja Stanisavljevic 1, Marketa Vaculovicova 1,2, Marie Stiborova 3, Tomas Eckschlager 4, Rene Kizek 1,2 and Vojtech Adam 1,2,*
1
Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University in Brno, Zemedelska 1, Brno CZ-613 00, Czech Republic
2
Central European Institute of Technology, Brno University of Technology, Technicka 3058/10, Brno CZ-616 00, Czech Republic
3
Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, Prague 2 CZ-128 40, Czech Republic
4
Department of Paediatric Haematology and Oncology, 2nd Faculty of Medicine and University Hospital Motol, Charles University, V Uvalu 84, Prague 5 CZ-150 06, Czech Republic
*
Author to whom correspondence should be addressed.
Received: 19 April 2013 / Revised: 18 May 2013 / Accepted: 23 May 2013 / Published: 27 June 2013
(This article belongs to the Special Issue Magnetic Nanoparticles 2013)
Abstract
Magnetic particle mediated transport in combination with nanomaterial based drug carrier has a great potential for targeted cancer therapy. In this study, doxorubicin encapsulation into the apoferritin and its conjugation with magnetic particles was investigated by capillary electrophoresis with laser-induced fluorescence detection (CE-LIF). The quantification of encapsulated doxorubicin was performed by fluorescence spectroscopy and compared to CE-LIF. Moreover, the significant enhancement of the doxorubicin signal was observed by addition of methanol into the sample solution. View Full-TextKeywords:
cancer; nanomedicine; magnetic particles; doxorubicin; nanoparticles
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Blazkova, I.; Nguyen, H.V.; Dostalova, S.; Kopel, P.; Stanisavljevic, M.; Vaculovicova, M.; Stiborova, M.; Eckschlager, T.; Kizek, R.; Adam, V. Apoferritin Modified Magnetic Particles as Doxorubicin Carriers for Anticancer Drug Delivery. Int. J. Mol. Sci. 2013, 14, 13391-13402.
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