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Article

Oxidative Stress Mediates the Disruption of Airway Epithelial Tight Junctions through a TRPM2-PLCγ1-PKCα Signaling Pathway

1
Department of Respiratory Medicine, the Second Affiliated Hospital, Chongqing University of Medical Science, Chongqing 400010, China
2
Far Eastern Scientific Center of Physiology and Pathology of Respiration, Russian Academy of Medical Sciences, Blagoveschensk 675000, Russia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2013, 14(5), 9475-9486; https://doi.org/10.3390/ijms14059475
Received: 24 January 2013 / Revised: 18 March 2013 / Accepted: 16 April 2013 / Published: 29 April 2013
(This article belongs to the Special Issue Oxidative Stress and Ageing)
Oxidative stress has been implicated as an important contributing factor in the pathogenesis of several pulmonary inflammatory diseases. Previous studies have indicated a relationship between oxidative stress and the attenuation of epithelial tight junctions (TJs). In Human Bronchial Epithelial-16 cells (16HBE), we demonstrated the degradation of zonula occludens-1 (ZO-1), and claudin-2 exhibited a great dependence on the activation of the transient receptor potential melastatin (TRPM) 2 channel, phospholipase Cγ1 (PLCγ1) and the protein kinase Cα (PKCα) signaling cascade. View Full-Text
Keywords: oxidative stress; tight junctions; TRPM2; PLCγ1; PKCα oxidative stress; tight junctions; TRPM2; PLCγ1; PKCα
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MDPI and ACS Style

Xu, R.; Li, Q.; Zhou, X.-D.; Perelman, J.M.; Kolosov, V.P. Oxidative Stress Mediates the Disruption of Airway Epithelial Tight Junctions through a TRPM2-PLCγ1-PKCα Signaling Pathway. Int. J. Mol. Sci. 2013, 14, 9475-9486. https://doi.org/10.3390/ijms14059475

AMA Style

Xu R, Li Q, Zhou X-D, Perelman JM, Kolosov VP. Oxidative Stress Mediates the Disruption of Airway Epithelial Tight Junctions through a TRPM2-PLCγ1-PKCα Signaling Pathway. International Journal of Molecular Sciences. 2013; 14(5):9475-9486. https://doi.org/10.3390/ijms14059475

Chicago/Turabian Style

Xu, Rui, Qi Li, Xiang-Dong Zhou, Juliy M. Perelman, and Victor P. Kolosov 2013. "Oxidative Stress Mediates the Disruption of Airway Epithelial Tight Junctions through a TRPM2-PLCγ1-PKCα Signaling Pathway" International Journal of Molecular Sciences 14, no. 5: 9475-9486. https://doi.org/10.3390/ijms14059475

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