Exercise Therapy Augments the Ischemia-Induced Proangiogenic State and Results in Sustained Improvement after Stroke
Abstract
:1. Introduction
2. Results and Discussion
2.1. Neurobehavioral Scores
2.2. Infarct Volume
2.3. Running Enhances MMP2 and VEGF mRNA Levels
2.4. Effect of Running on MMP2 and VEGF Protein Expressions and the Effect of BEV
2.5. Running Increases rCBF
2.6. Discussion
3. Experimental Section
3.1. Animals and Treatment
3.2. Cerebral Ischemia and Measurement of Physiological Parameters
3.3. Neurobehavioral Tests
3.4. Measurement of Cerebral Infarction Volume
3.5. Reverse-Transcription Polymerase Chain Reaction
3.6. Western Blot Analysis
3.7. CBF Measurements
3.8. Statistical Analysis
4. Conclusions
Acknowledgments
Conflict of Interest
References
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Group | Number | MCAo/R | BEV Treatment | Time for Running (hours post MCAO) | Duration of Running (days) | Timing for Sacrifice after MCAo (days) |
---|---|---|---|---|---|---|
1 | 5 | - | - | - | - | 0 |
2 | 5 | + | - | - | - | 1 |
3 | 5 | + | - | 48 | 3 | 5 |
4 | 5 | + | - | 48 | 7 | 9 |
5 | 15 | + | - | 48 | 14 | 16 |
6 | 5 | + | - | - | - | 5 |
7 | 5 | + | - | - | - | 9 |
8 | 15 | + | - | - | - | 16 |
9 | 10 | + | + | 48 | 14 | 16 |
10 | 10 | + | + | - | - | 16 |
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Ma, Y.; Qiang, L.; He, M. Exercise Therapy Augments the Ischemia-Induced Proangiogenic State and Results in Sustained Improvement after Stroke. Int. J. Mol. Sci. 2013, 14, 8570-8584. https://doi.org/10.3390/ijms14048570
Ma Y, Qiang L, He M. Exercise Therapy Augments the Ischemia-Induced Proangiogenic State and Results in Sustained Improvement after Stroke. International Journal of Molecular Sciences. 2013; 14(4):8570-8584. https://doi.org/10.3390/ijms14048570
Chicago/Turabian StyleMa, Yuewen, Lin Qiang, and Man He. 2013. "Exercise Therapy Augments the Ischemia-Induced Proangiogenic State and Results in Sustained Improvement after Stroke" International Journal of Molecular Sciences 14, no. 4: 8570-8584. https://doi.org/10.3390/ijms14048570