Next Article in Journal
MICAL, the Flavoenzyme Participating in Cytoskeleton Dynamics
Next Article in Special Issue
Impact of High Salt Independent of Blood Pressure on PRMT/ADMA/DDAH Pathway in the Aorta of Dahl Salt-Sensitive Rats
Previous Article in Journal
Auxin and Cytokinin Metabolism and Root Morphological Modifications in Arabidopsis thaliana Seedlings Infected with Cucumber mosaic virus (CMV) or Exposed to Cadmium
Previous Article in Special Issue
The Protective Effects of α-Lipoic Acid on Kidneys in Type 2 Diabetic Goto-Kakisaki Rats via Reducing Oxidative Stress
Article Menu

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2013, 14(4), 6903-6919;

Beneficial Effects of the RESMENA Dietary Pattern on Oxidative Stress in Patients Suffering from Metabolic Syndrome with Hyperglycemia Are Associated to Dietary TAC and Fruit Consumption

Department of Nutrition, Food Sciences and Physiology, University of Navarra, Pamplona 31008, Spain
Department of Nutrition and Bromatology, The Complutense University of Madrid, Madrid 28040, Spain
CIBERobn Physiopathology of Obesity and Nutrition, Centre of Biomedical Research Network, Madrid 29029, Spain
Author to whom correspondence should be addressed.
Received: 30 January 2013 / Revised: 8 March 2013 / Accepted: 19 March 2013 / Published: 27 March 2013
(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease)
Full-Text   |   PDF [347 KB, uploaded 19 June 2014]


Hyperglycemia and oxidative stress are conditions directly related to the metabolic syndrome (MetS), whose prevalence is increasing worldwide. This study aimed to evaluate the effectiveness of a new weight-loss dietary pattern on improving the oxidative stress status on patients suffering MetS with hyperglycemia. Seventy-nine volunteers were randomly assigned to two low-calorie diets (−30% Energy): the control diet based on the American Health Association criteria and the RESMENA diet based on a different macronutrient distribution (30% proteins, 30% lipids, 40% carbohydrates), which was characterized by an increase of the meal frequency (seven-times/day), low glycemic load, high antioxidant capacity (TAC) and high n-3 fatty acids content. Dietary records, anthropometrical measurements, biochemical parameters and oxidative stress biomarkers were analyzed before and after the six-month-long study. The RESMENA (Metabolic Syndrome Reduction in Navarra) diet specifically reduced the android fat mass and demonstrated more effectiveness on improving general oxidative stress through a greater decrease of oxidized LDL (oxLDL) values and protection against arylesterase depletion. Interestingly, oxLDL values were associated with dietary TAC and fruit consumption and with changes on body mass index (BMI), waist circumference, fat mass and triacilglyceride (TG) levels. In conclusion, the antioxidant properties of the RESMENA diet provide further benefits to those attributable to weight loss on patients suffering Mets with hyperglycemia. View Full-Text
Keywords: metabolic syndrome; hyperglycemia; oxidative stress; TAC; fruit metabolic syndrome; hyperglycemia; oxidative stress; TAC; fruit
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

de la Iglesia, R.; Lopez-Legarrea, P.; Celada, P.; Sánchez-Muniz, F.J.; Martinez, J.A.; Zulet, M.A. Beneficial Effects of the RESMENA Dietary Pattern on Oxidative Stress in Patients Suffering from Metabolic Syndrome with Hyperglycemia Are Associated to Dietary TAC and Fruit Consumption. Int. J. Mol. Sci. 2013, 14, 6903-6919.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top