Next Article in Journal
Connecting Chromatin Modifying Factors to DNA Damage Response
Next Article in Special Issue
Epidermal Growth Factor Stimulates Extracellular-Signal Regulated Kinase Phosphorylation of a Novel Site on Cytoplasmic Dynein Intermediate Chain 2
Previous Article in Journal
Molecular Motions in Functional Self-Assembled Nanostructures
Previous Article in Special Issue
Regulation of Erythropoietin Receptor Activity in Endothelial Cells by Different Erythropoietin (EPO) Derivatives: An in Vitro Study
Article Menu

Export Article

Open AccessReview

Cell Survival and Apoptosis Signaling as Therapeutic Target for Cancer: Marine Bioactive Compounds

Marine Bioprocess Research Center, Department of Chemistry, Pukyong National University, Busan 608-737, Korea
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2013, 14(2), 2334-2354;
Received: 16 November 2012 / Revised: 10 January 2013 / Accepted: 11 January 2013 / Published: 24 January 2013
(This article belongs to the Special Issue Signalling Molecules and Signal Transduction in Cells)
PDF [481 KB, uploaded 19 June 2014]


Inhibition of apoptosis leads to activation of cell survival factors (e.g., AKT) causes continuous cell proliferation in cancer. Apoptosis, the major form of cellular suicide, is central to various physiological processes and the maintenance of homeostasis in multicellular organisms. A number of discoveries have clarified the molecular mechanism of apoptosis, thus clarifying the link between apoptosis and cell survival factors, which has a therapeutic outcome. Induction of apoptosis and inhibition of cell survival by anticancer agents has been shown to correlate with tumor response. Cellular damage induces growth arrest and tumor suppression by inducing apoptosis, necrosis and senescence; the mechanism of cell death depends on the magnitude of DNA damage following exposure to various anticancer agents. Apoptosis is mainly regulated by cell survival and proliferating signaling molecules. As a new therapeutic strategy, alternative types of cell death might be exploited to control and eradicate cancer cells. This review discusses the signaling of apoptosis and cell survival, as well as the potential contribution of marine bioactive compounds, suggesting that new therapeutic strategies might follow. View Full-Text
Keywords: apoptosis; cell survival; AKT; Bax; marine compounds apoptosis; cell survival; AKT; Bax; marine compounds

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Kalimuthu, S.; Se-Kwon, K. Cell Survival and Apoptosis Signaling as Therapeutic Target for Cancer: Marine Bioactive Compounds. Int. J. Mol. Sci. 2013, 14, 2334-2354.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top