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Article

Aberrant Expression of Posterior HOX Genes in Well Differentiated Histotypes of Thyroid Cancers

by
Monica Cantile
1,†,
Giosuè Scognamiglio
1,†,
Lucia La Sala
1,
Elvira La Mantia
1,
Veronica Scaramuzza
1,
Elena Valentino
1,
Fabiana Tatangelo
1,
Simona Losito
1,
Luciano Pezzullo
2,
Maria Grazia Chiofalo
2,
Franco Fulciniti
1,
Renato Franco
1,* and
Gerardo Botti
1
1
Pathology Unit, National Cancer Institute "G. Pascale" Foundation, via Mariano Semmola 80131, Napoli, Italy
2
Thyroid and Parathyroid Surgery Unit, National Cancer Institute "G. Pascale" Foundation, via Mariano Semmola 80131, Napoli, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2013, 14(11), 21727-21740; https://doi.org/10.3390/ijms141121727
Submission received: 25 September 2013 / Revised: 14 October 2013 / Accepted: 17 October 2013 / Published: 1 November 2013
(This article belongs to the Special Issue Molecular Bases of Cancer Research)
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Abstract

Molecular etiology of thyroid cancers has been widely studied, and several molecular alterations have been identified mainly associated with follicular and papillary histotypes. However, the molecular bases of the complex pathogenesis of thyroid carcinomas remain poorly understood. HOX genes regulate normal embryonic development, cell differentiation and other critical processes in eukaryotic cell life. Several studies have shown that HOX genes play a role in neoplastic transformation of several human tissues. In particular, the genes belonging to HOX paralogous group 13 seem to hold a relevant role in both tumor development and progression. We have identified a significant prognostic role of HOX D13 in pancreatic cancer and we have recently showed the strong and progressive over-expression of HOX C13 in melanoma metastases and deregulation of HOX B13 expression in bladder cancers. In this study we have investigated, by immunohistochemisty and quantitative Real Time PCR, the HOX paralogous group 13 genes/proteins expression in thyroid cancer evolution and progression, also evaluating its ability to discriminate between main histotypes. Our results showed an aberrant expression, both at gene and protein level, of all members belonging to paralogous group 13 (HOX A13, HOX B13, HOX C13 and HOX D13) in adenoma, papillary and follicular thyroid cancers samples. The data suggest a potential role of HOX paralogous group 13 genes in pathogenesis and differential diagnosis of thyroid cancers.
Keywords: HOX 13 paralogous genes; thyroid histotypes; thyroid tumors progression HOX 13 paralogous genes; thyroid histotypes; thyroid tumors progression

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MDPI and ACS Style

Cantile, M.; Scognamiglio, G.; La Sala, L.; La Mantia, E.; Scaramuzza, V.; Valentino, E.; Tatangelo, F.; Losito, S.; Pezzullo, L.; Chiofalo, M.G.; et al. Aberrant Expression of Posterior HOX Genes in Well Differentiated Histotypes of Thyroid Cancers. Int. J. Mol. Sci. 2013, 14, 21727-21740. https://doi.org/10.3390/ijms141121727

AMA Style

Cantile M, Scognamiglio G, La Sala L, La Mantia E, Scaramuzza V, Valentino E, Tatangelo F, Losito S, Pezzullo L, Chiofalo MG, et al. Aberrant Expression of Posterior HOX Genes in Well Differentiated Histotypes of Thyroid Cancers. International Journal of Molecular Sciences. 2013; 14(11):21727-21740. https://doi.org/10.3390/ijms141121727

Chicago/Turabian Style

Cantile, Monica, Giosuè Scognamiglio, Lucia La Sala, Elvira La Mantia, Veronica Scaramuzza, Elena Valentino, Fabiana Tatangelo, Simona Losito, Luciano Pezzullo, Maria Grazia Chiofalo, and et al. 2013. "Aberrant Expression of Posterior HOX Genes in Well Differentiated Histotypes of Thyroid Cancers" International Journal of Molecular Sciences 14, no. 11: 21727-21740. https://doi.org/10.3390/ijms141121727

APA Style

Cantile, M., Scognamiglio, G., La Sala, L., La Mantia, E., Scaramuzza, V., Valentino, E., Tatangelo, F., Losito, S., Pezzullo, L., Chiofalo, M. G., Fulciniti, F., Franco, R., & Botti, G. (2013). Aberrant Expression of Posterior HOX Genes in Well Differentiated Histotypes of Thyroid Cancers. International Journal of Molecular Sciences, 14(11), 21727-21740. https://doi.org/10.3390/ijms141121727

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