Chemical Constituents from Andrographis echioides and Their Anti-Inflammatory Activity

Shen, De-Yang; Juang, Shin-Hun; Kuo, Ping-Chung; Huang, Guan-Jhong; Chan, Yu-Yi; Damu, Amooru G.; Wu, Tian-Shung

doi:10.3390/ijms14010496

Open AccessArticle

Chemical Constituents from Andrographis echioides and Their Anti-Inflammatory Activity

by

De-Yang Shen

^1,†,

Shin-Hun Juang

^2,†,

Ping-Chung Kuo

^3,†,

Guan-Jhong Huang

⁴,

Yu-Yi Chan

⁵,

Amooru G. Damu

¹ and

Tian-Shung Wu

^1,4,6,*

¹

Department of Chemistry, National Cheng Kung University, Tainan 70101, Taiwan

²

Graduate Institute of Pharmaceutical Chemistry, China Medical University, No. 91, Hsueh-Shih Road, Taichung 40402, Taiwan

³

Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan

⁴

Department of Pharmacy, China Medical University, Taichung 40402, Taiwan

⁵

Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan 71005, Taiwan

⁶

Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 40402, Taiwan

^*

Author to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Int. J. Mol. Sci. 2013, 14(1), 496-514; https://doi.org/10.3390/ijms14010496

Submission received: 12 November 2012 / Revised: 11 December 2012 / Accepted: 17 December 2012 / Published: 27 December 2012

(This article belongs to the Special Issue Plant-Derived Pharmaceuticals by Molecular Farming 2012)

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Abstract

Phytochemical investigation of the whole plants of Andrographis echioides afforded two new 2'-oxygenated flavonoids (1) and (2), two new phenyl glycosides (3) and (4), along with 37 known structures. The structures of new compounds were elucidated by spectral analysis and chemical transformation studies. Among the isolated compounds, (1–2) and (6–19) were subjected into the examination for their iNOS inhibitory bioactivity. The structure-activity relationships of the flavonoids for their inhibition of NO production were also discussed.

Keywords: Andrographis echioides; flavonoid; anti-inflammatory; iNOS

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MDPI and ACS Style

Shen, D.-Y.; Juang, S.-H.; Kuo, P.-C.; Huang, G.-J.; Chan, Y.-Y.; Damu, A.G.; Wu, T.-S. Chemical Constituents from Andrographis echioides and Their Anti-Inflammatory Activity. Int. J. Mol. Sci. 2013, 14, 496-514. https://doi.org/10.3390/ijms14010496

AMA Style

Shen D-Y, Juang S-H, Kuo P-C, Huang G-J, Chan Y-Y, Damu AG, Wu T-S. Chemical Constituents from Andrographis echioides and Their Anti-Inflammatory Activity. International Journal of Molecular Sciences. 2013; 14(1):496-514. https://doi.org/10.3390/ijms14010496

Chicago/Turabian Style

Shen, De-Yang, Shin-Hun Juang, Ping-Chung Kuo, Guan-Jhong Huang, Yu-Yi Chan, Amooru G. Damu, and Tian-Shung Wu. 2013. "Chemical Constituents from Andrographis echioides and Their Anti-Inflammatory Activity" International Journal of Molecular Sciences 14, no. 1: 496-514. https://doi.org/10.3390/ijms14010496

APA Style

Shen, D.-Y., Juang, S.-H., Kuo, P.-C., Huang, G.-J., Chan, Y.-Y., Damu, A. G., & Wu, T.-S. (2013). Chemical Constituents from Andrographis echioides and Their Anti-Inflammatory Activity. International Journal of Molecular Sciences, 14(1), 496-514. https://doi.org/10.3390/ijms14010496

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Chemical Constituents from Andrographis echioides and Their Anti-Inflammatory Activity

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