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Int. J. Mol. Sci. 2013, 14(1), 496-514;

Chemical Constituents from Andrographis echioides and Their Anti-Inflammatory Activity

Department of Chemistry, National Cheng Kung University, Tainan 70101, Taiwan
Graduate Institute of Pharmaceutical Chemistry, China Medical University, No. 91, Hsueh-Shih Road, Taichung 40402, Taiwan
Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan
Department of Pharmacy, China Medical University, Taichung 40402, Taiwan
Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan 71005, Taiwan
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 40402, Taiwan
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 12 November 2012 / Revised: 11 December 2012 / Accepted: 17 December 2012 / Published: 27 December 2012
(This article belongs to the Special Issue Plant-Derived Pharmaceuticals by Molecular Farming 2012)
Full-Text   |   PDF [341 KB, uploaded 19 June 2014]


Phytochemical investigation of the whole plants of Andrographis echioides afforded two new 2'-oxygenated flavonoids (1) and (2), two new phenyl glycosides (3) and (4), along with 37 known structures. The structures of new compounds were elucidated by spectral analysis and chemical transformation studies. Among the isolated compounds, (12) and (619) were subjected into the examination for their iNOS inhibitory bioactivity. The structure-activity relationships of the flavonoids for their inhibition of NO production were also discussed. View Full-Text
Keywords: Andrographis echioides; flavonoid; anti-inflammatory; iNOS Andrographis echioides; flavonoid; anti-inflammatory; iNOS
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Shen, D.-Y.; Juang, S.-H.; Kuo, P.-C.; Huang, G.-J.; Chan, Y.-Y.; Damu, A.G.; Wu, T.-S. Chemical Constituents from Andrographis echioides and Their Anti-Inflammatory Activity. Int. J. Mol. Sci. 2013, 14, 496-514.

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