Next Article in Journal / Special Issue
Self-Assembly of Discrete Metal Complexes in Aqueous Solution via Block Copolypeptide Amphiphiles
Previous Article in Journal
Quantitative and Chemical Fingerprint Analysis for the Quality Evaluation of Receptaculum Nelumbinis by RP-HPLC Coupled with Hierarchical Clustering Analysis
Previous Article in Special Issue
Aqueous Self-Sorting in Extended Supramolecular Aggregates
Open AccessArticle

Catalysis of Transesterification Reactions by a Self-Assembled Nanosystem

Department of Chemical Sciences, University of Padova, Via Marzolo 1, 35131 Padova, Italy
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2013, 14(1), 2011-2021; https://doi.org/10.3390/ijms14012011
Received: 30 November 2012 / Accepted: 14 January 2013 / Published: 21 January 2013
(This article belongs to the Special Issue Molecular Self-Assembly 2012)
Histidine-containing peptides self-assemble on the surface of monolayer protected gold nanoparticles to form a catalytic system for transesterification reactions. Self-assembly is a prerequisite for catalysis, since the isolated peptides do not display catalytic activity by themselves. A series of catalytic peptides and substrates are studied in order to understand the structural parameters that are of relevance to the catalytic efficiency of the system. It is shown that the distance between the His-residue and the anionic tail does not affect the catalytic activity. On the other hand, the catalytic His-residue is sensitive to the chemical nature of the flanking amino acid residues. In particular, the presence of polar Ser-residues causes a significant increase in activity. Finally, kinetic studies of a series of substrates reveal that substrates with a hydrophobic component are very suitable for this catalytic system. View Full-Text
Keywords: supramolecular catalysis; peptides; nanoparticles; self-assembly supramolecular catalysis; peptides; nanoparticles; self-assembly
Show Figures

Graphical abstract

MDPI and ACS Style

Zaramella, D.; Scrimin, P.; Prins, L.J. Catalysis of Transesterification Reactions by a Self-Assembled Nanosystem. Int. J. Mol. Sci. 2013, 14, 2011-2021.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop