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Int. J. Mol. Sci. 2012, 13(8), 10608-10629;

Recent Advances on the Neuroprotective Potential of Antioxidants in Experimental Models of Parkinson’s Disease

Department of Biotechnology, Konkuk University, Chungju 380-701, Korea
Author to whom correspondence should be addressed.
Received: 26 July 2012 / Revised: 13 August 2012 / Accepted: 14 August 2012 / Published: 23 August 2012
(This article belongs to the Special Issue Neuroprotective Strategies 2012)
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Parkinson’s disease (PD), a neurodegenerative movement disorder of the central nervous system (CNS) is characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta region of the midbrain. Although the etiology of PD is not completely understood and is believed to be multifactorial, oxidative stress and mitochondrial dysfunction are widely considered major consequences, which provide important clues to the disease mechanisms. Studies have explored the role of free radicals and oxidative stress that contributes to the cascade of events leading to dopamine cell degeneration in PD. In general, in-built protective mechanisms consisting of enzymatic and non-enzymatic antioxidants in the CNS play decisive roles in preventing neuronal cell loss due to free radicals. But the ability to produce these antioxidants decreases with aging. Therefore, antioxidant therapy alone or in combination with current treatment methods may represent an attractive strategy for treating or preventing the neurodegeneration seen in PD. Here we summarize the recent discoveries of potential antioxidant compounds for modulating free radical mediated oxidative stress leading to neurotoxicity in PD. View Full-Text
Keywords: Parkinson’s disease; oxidative stress; free radicals; antioxidants; neuroprotection Parkinson’s disease; oxidative stress; free radicals; antioxidants; neuroprotection
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Koppula, S.; Kumar, H.; More, S.V.; Kim, B.W.; Kim, I.S.; Choi, D.-K. Recent Advances on the Neuroprotective Potential of Antioxidants in Experimental Models of Parkinson’s Disease. Int. J. Mol. Sci. 2012, 13, 10608-10629.

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