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Open AccessCommunication
Int. J. Mol. Sci. 2012, 13(3), 3765-3772;

Production of Protocatechuic Acid in Bacillus Thuringiensis ATCC33679

Department of Biology, Tougaloo College, Tougaloo, MS 39174, USA
Center for Bioinformatics and Computational Biology, Department of Biology, Jackson State University, Jackson, MS 39217, USA
Author to whom correspondence should be addressed.
Received: 29 January 2012 / Revised: 16 March 2012 / Accepted: 19 March 2012 / Published: 21 March 2012
(This article belongs to the Section Biochemistry)
Full-Text   |   PDF [167 KB, uploaded 19 June 2014]


Protocatechuic acid, or 3,4-dihydroxybenzoic acid, is produced by both soil and marine bacteria in the free form and as the iron binding component of the siderophore petrobactin. The soil bacterium, Bacillus thuringiensis kurstaki ATCC 33679, contains the asb operon, but does not produce petrobactin. Iron restriction resulted in diminished B. thuringiensis kurstaki ATCC 33679 growth and the production of catechol(s). The gene product responsible for protocatechuic acid (asbF) and its receptor (fatB) were expressed during stationary phase growth. Gene expression varied with growth temperature, with optimum levels occurring well below the Bacillus anthracis virulence temperature of 37 °C. Regulation of protocatechuic acid suggests a possible role for this compound during soil growth cycles. View Full-Text
Keywords: catechol; Bacillus; protocatechuic acid catechol; Bacillus; protocatechuic acid
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Williams, K.M.; Martin, W.E.; Smith, J.; Williams, B.S.; Garner, B.L. Production of Protocatechuic Acid in Bacillus Thuringiensis ATCC33679. Int. J. Mol. Sci. 2012, 13, 3765-3772.

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