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Int. J. Mol. Sci. 2012, 13(2), 1846-1857;

The -308G/A of Tumor Necrosis Factor (TNF)-α and 825C/T of Guanidine Nucleotide Binding Protein 3 (GNB3) are Associated with the Onset of Acute Myocardial Infarction and Obesity in Taiwan

Division of Cardiology, Kaohsiung Armed Forces General Hospital, Kaohsiung 802, Taiwan
Department of Biological Science and Technology of I-Shou University, Kaohsiung 840, Taiwan
Department of Biomedical Research, Asia-Pacific Biotech Developing, Kaohsiung 806, Taiwan
Institute of Biomedical Sciences of National Sun Yat-Sen University, Kaohsiung 804, Taiwan
Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung 402, Taiwan
Clinical Laboratory, Chung Shan Medical University Hospital, Taichung 402, Taiwan
Author to whom correspondence should be addressed.
Received: 14 December 2011 / Revised: 23 January 2012 / Accepted: 3 February 2012 / Published: 9 February 2012
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Full-Text   |   PDF [278 KB, uploaded 19 June 2014]


Acute myocardial infarction is a highly prevalent cardiovascular disease in Taiwan. Among several etiological risk factors, obesity and inflammation are strongly associated with the frequency of hypertension, cardiovascular disease, diabetes, and myocardial infarction. To discriminate obesity- and inflammation-related genes and the onset of acute myocardial infarction (AMI), a case-control study was conducted to investigate the association of the -308G/A polymorphisms of tumor necrosis factor (TNF)-α and the C825T polymorphism of guanidine nucleotide binding protein 3 (GNB3) with the onset of AMI among Taiwanese cohorts. A total of 103 AMI patients and 163 matched normal control samples were enrolled in the present study. The genomic DNA was extracted and subjected into polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) analysis. An association between the A homozygosity of the TNF-α-308G/A polymorphism and the onset of AMI was observed among the male subjects (p = 0.026; Spearman index = 0.200, p = 0.008). An association between the T homozygosity of GNB3 C825T polymorphism and obesity was also observed (Fisher’s exact, p = 0.009). The TT genotype has a protective effect against acquiring AMI among the obese female population in Taiwan (Fisher’s exact, p = 0.032). In conclusion, TNF-α-308G/A and the GNB3 C825T polymorphisms are associated with obesity and AMI in the Taiwanese population. View Full-Text
Keywords: acute myocardial infarction; gene polymorphisms; GNB-3; TNF-alpha
acute myocardial infarction; gene polymorphisms; GNB-3; TNF-alpha
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Chang, W.-T.; Wang, Y.-C.; Chen, C.-C.; Zhang, S.-K.; Liu, C.-H.; Chang, F.-H.; Hsu, L.-S. The -308G/A of Tumor Necrosis Factor (TNF)-α and 825C/T of Guanidine Nucleotide Binding Protein 3 (GNB3) are Associated with the Onset of Acute Myocardial Infarction and Obesity in Taiwan. Int. J. Mol. Sci. 2012, 13, 1846-1857.

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