p66Shc Aging Protein in Control of Fibroblasts Cell Fate
Abstract
:1. Introduction
2. Age-Related Dysfunctions of the Mitochondrial Respiratory Chain and Antioxidant Defense
2.1. Antioxidant Defense and Aging
2.2. Antioxidant Supplementation
3. p66Shc—The Oxidative Stress and Longevity
4. p66Shc—One Protein Two Functions
5. A New Job for p66Shc: Its Role in Adipocyte Metabolism
6. Studies on p66Shc in Fibroblast Models
7. Mitochondrial Ca2+ Homeostasis is Compromised in Senescent Cells through a p66Shc Dependent Pathway
8. p66Shc Pathway Is Activated by Intracellular Oxidative Stress—Studies on Fibroblasts from Patients Harboring Mitochondrial Defects
9. Concluding Remarks
Ethics
Acknowledgments
- Conflict of InterestThe authors have declared no conflicts of interest.
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Suski, J.M.; Karkucinska-Wieckowska, A.; Lebiedzinska, M.; Giorgi, C.; Szczepanowska, J.; Szabadkai, G.; Duszynski, J.; Pronicki, M.; Pinton, P.; Wieckowski, M.R. p66Shc Aging Protein in Control of Fibroblasts Cell Fate. Int. J. Mol. Sci. 2011, 12, 5373-5389. https://doi.org/10.3390/ijms12085373
Suski JM, Karkucinska-Wieckowska A, Lebiedzinska M, Giorgi C, Szczepanowska J, Szabadkai G, Duszynski J, Pronicki M, Pinton P, Wieckowski MR. p66Shc Aging Protein in Control of Fibroblasts Cell Fate. International Journal of Molecular Sciences. 2011; 12(8):5373-5389. https://doi.org/10.3390/ijms12085373
Chicago/Turabian StyleSuski, Jan M., Agnieszka Karkucinska-Wieckowska, Magdalena Lebiedzinska, Carlotta Giorgi, Joanna Szczepanowska, Gyorgy Szabadkai, Jerzy Duszynski, Maciej Pronicki, Paolo Pinton, and Mariusz R. Wieckowski. 2011. "p66Shc Aging Protein in Control of Fibroblasts Cell Fate" International Journal of Molecular Sciences 12, no. 8: 5373-5389. https://doi.org/10.3390/ijms12085373