Mechanisms of Mycotoxin-Induced Neurotoxicity through Oxidative Stress-Associated Pathways
1
Nippon Institute for Biological Science, 9-2221-1, Shin-Machi, Ome, Tokyo 198-0024, Japan
2
Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo, Tokyo 113-8657, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2011, 12(8), 5213-5237; https://doi.org/10.3390/ijms12085213
Received: 7 June 2011
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Revised: 21 July 2011
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Accepted: 4 August 2011
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Published: 15 August 2011
(This article belongs to the Section Molecular Toxicology)
Among many mycotoxins, T-2 toxin, macrocyclic trichothecenes, fumonisin B1 (FB1) and ochratochin A (OTA) are known to have the potential to induce neurotoxicity in rodent models. T-2 toxin induces neuronal cell apoptosis in the fetal and adult brain. Macrocyclic trichothecenes bring about neuronal cell apoptosis and inflammation in the olfactory epithelium and olfactory bulb. FB1 induces neuronal degeneration in the cerebral cortex, concurrent with disruption of de novo ceramide synthesis. OTA causes acute depletion of striatal dopamine and its metabolites, accompanying evidence of neuronal cell apoptosis in the substantia nigra, striatum and hippocampus. This paper reviews the mechanisms of neurotoxicity induced by these mycotoxins especially from the viewpoint of oxidative stress-associated pathways.
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Keywords:
neurotoxicity; T-2 toxin; macrocyclic trichothecenes; fumonisin B1; ochratoxin A
This is an open access article distributed under the Creative Commons Attribution License
MDPI and ACS Style
Doi, K.; Uetsuka, K. Mechanisms of Mycotoxin-Induced Neurotoxicity through Oxidative Stress-Associated Pathways. Int. J. Mol. Sci. 2011, 12, 5213-5237. https://doi.org/10.3390/ijms12085213
AMA Style
Doi K, Uetsuka K. Mechanisms of Mycotoxin-Induced Neurotoxicity through Oxidative Stress-Associated Pathways. International Journal of Molecular Sciences. 2011; 12(8):5213-5237. https://doi.org/10.3390/ijms12085213
Chicago/Turabian StyleDoi, Kunio, and Koji Uetsuka. 2011. "Mechanisms of Mycotoxin-Induced Neurotoxicity through Oxidative Stress-Associated Pathways" International Journal of Molecular Sciences 12, no. 8: 5213-5237. https://doi.org/10.3390/ijms12085213
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